高膽固醇飲食添加紅麴粉末及黃豆固醇對倉鼠體內脂質代謝及抗氧化酵素之影響

Effects of Monascus Rice Powder and Soysterols on Lipid Metabolism and Antioxidative Enzymes in Hamsters

謝孟志(Meng-Jyh Shieh) ； 黃士懿(Shih-Yi Huang) ； 錢信(Hsin Chien) ； 楊惠婷(Hui-Ting Yang) ； 劉佩姎(Pei-Yang Liu) ； 劉姚伶(Yao-Ling Liu) ； 謝明哲(Ming-Jer Shieh)

《中華民國營養學會雜誌》 26卷1期 (2001/03) Pp. 32-40

https://doi.org/10.6691/JCNS.200103_26(1).0004

摘要

本實驗目的在探討比較單獨給予黃豆固醇或紅麴粉末和同時給予黃豆固醇及紅麴粉末對倉鼠體內脂質代謝及抗氧化酵素活性之影響。56隻四週大雄性倉鼠，體重120 g，隨機分成6組，以AIN-76配方為基本飲食，添加0.1%膽固醇為控制組（C組）；黃豆固醇組（S組）以控制組飼料添加2.5% s（MS1組），0.8%M + 1.0% S（MS2組）及0.4% M + 0.5% S(MS3組)；餵食四週後犧牲老鼠，測肝臟及血脂肪，血球GSH-Px、全血SOD活性，糞便膽固醇及膽酸。結果顯示，黃豆固醇及紅麴粉末無論是單獨或合併添加到控制組飼料中，都降低肝臟脂質，血清低密度脂蛋白膽固醇、三酸甘油酯濃度及低／高密度脂蛋白膽固醇比值，並且合併使用效果大於各自單獨使用，其中以MS3效果最好。在糞便膽固醇及膽酸方面，糞便膽固醇每日排出量和肝臟膽固醇含量呈正相關，而S組有增加，但M組減少膽酸每日排出量趨勢。在抗氧化酵素活性方面，各組間對GSH-Px活性無顯著差異，但M組卻有增加SOD活性，而S組減少SOD活性的趨勢。

關鍵字

紅麴粉末 ； 黃豆固醇 ； 膽固醇 ； 三酸甘油酯 ； 超氧化物歧化酶 ； 麩胱甘肽過氧化酶

並列摘要

This study evaluated the cholesterol-lowering effectiveness and plasma antioxidative enzymes produced by Monascus rice powder and soysterols in hamsters. Fifty-four weanling male hamsters were divided into six treatment groups (C, control diet; S, 2.5% soysterol diet; M, 1.0% monacolin diet; MS1, combines with 2.5% soysterol and 2.0% monacolin diet; MS2, 1.0% S + 0.8% M;MS3, 0.5% S + 0.4%M) and induced with hypercholesterolemia for this study. Single or combined doses of Monascus rice powder and soysterols were administrated in the study for 4 weeks. After treatment, blood and liver samples were taken for lipid profiles and antioxidative enzyme activity analysis. Results indicated that the plasma and hepatic TG, cholesterol levels and the ratio of LDL/HDL decreased in the Monascus rice powder and soysterols combined groups. The lipid accumulation in the liver also diminished over the four-week administration. Further-more, the combined groups presented more effective cholesterol-lowering ability. From the dose viewpoint, the highest dose of Monascus rice powder and soysterols presented the greatest effectiveness in lowering plasma cholesterol and hepatic lipid accumulation. Moreover, the combined Monascus ric powder and soysterols increased cholesterol and bile acid excretion, however the Monascus rice powder diet tended to decrease bile acid execretion. The RBC glutathione peroxidase and whole blood superoxide dismutase activity showed no significant difference among combined groups, however Monascus rice powder alone diet tended to elevate the superoxide dismutase activity.

並列關鍵字

monascus rice powder ； soysterol ； cholesterol ； triglyceride ； glutathione peroxidase ； superoxide dismutase