Title

The Optimal Cut-off Value of Abdominal Aortic Calcification Score in Predicting Mortality in Chronic Hemodialysis Patients

DOI

10.6221/AN.201812_32(4).0003

Authors

Wei-Ting Wang;Chieh-Ning Hsi;Hsuan-Jen Lin;Che-Yi Chou;Shi-Heng Wang;Hung-Chih Chen;Chiz-Tzung Chang

Key Words

AAC score ; abdominal aortic calcification score ; ESRD ; hemodialysis ; mortality

PublicationName

Acta Nephrologica

Volume or Term/Year and Month of Publication

32卷4期(2018 / 12 / 01)

Page #

160 - 166

Content Language

英文

Chinese Abstract

BACKGROUND: Abdominal aortic calcification (AAC) is associated with increased mortality in hemodialysis (HD) patients. However, the cut-off value of AAC score in predicting all-cause mortality is unknown. We aimed to explore the optimal cut-off value of AAC score in predicting all-cause mortality in HD patients. METHODS: We measured the AAC scores of all HD patients in China Medical University Hospital, and the association between AAC score and all-cause mortality was analyzed using Cox regression. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off of AAC score. RESULTS: A total of 410 patients were enrolled in this study. In the total follow-up time of 59 months, 112 (27.3%) patients died at the end of the study. The AAC score was associated with increased all-cause mortality with an adjusted hazard ratio of 1.052 (95% confidence interval [CI]: 1.019-1.085 for every one-point increase of AAC score) (P = 0.002). The area under the ROC curve was 0.617 (P < 0.001) for AAC score. The sensitivity and specificity of the AAC score were 53.6 and 79.2% with a cut-off of 11. The survival of patients with an AAC score < 11 was better than those with an AAC score of ≥ 11 (log-rank test, P < 0.001). CONCLUSION: A higher AAC score was associated with increased all-cause mortality in chronic HD patients. The optimal cut-off of the AAC score was 11 in predicting all-cause mortality.

Topic Category 醫藥衛生 > 內科