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Association between Particulate Matter Exposure and Short-term Prognosis in Patients with Pneumonia

摘要


Particulate matter (PM) and other air pollutants are reportedly associated with both lung and systemic inflammation; however, an association between air pollutants and pneumonia outcomes has not been well established. Therefore, we evaluated the effect of air pollutants on the short-term outcomes of emergency department patients with pneumonia. We collected data on PM_(2.5) (aerodynamic diameter < 2.5 μm), PM_(10) (aerodynamic diameter < 10 μm), sulfur dioxide (SO_2), nitrogen dioxide (NO_2), and ozone from 11 air-quality monitoring stations in Kaohsiung City between January 1, 2008, and December 31, 2013. Medical records were extracted for non-trauma patients aged > 17 years who had visited the emergency department with a principal diagnosis of pneumonia. In-hospital mortality and the association of air pollutant exposure with the need for invasive respiratory and/or vasopressor support (IRVS) within 72 h were evaluated. Interquartile range (IQR) increments of PM_(2.5) and PM_(10) were associated with an increased IRVS risk with odds ratios (ORs) of 1.211 (95% confidence interval [CI], 1.031-1.419) and 1.194 (95% CI, 1.020-1.394) on lag 1, respectively, and per-IQR increments of NO_2 were associated with an increased IRVS risk with an OR of 1.146 (95% CI, 1.004-1.308) on lag 2. IQR increments of PM_(2.5) and NO_2 were associated with an increased in-hospital mortality risk with ORs of 1.202 (95% CI, 1.100-1.429) and 1.175 (95% CI, 1.014-1.360), respectively. During the warm season, IQR increments of PM_(2.5), PM_(10), and NO_2 corresponded with an increased IRVS risk, with ORs of 1.333 (95% CI, 1.078-1.644), 1.348 (95% CI, 1.090-1.665), and 1.321 (95% CI, 1.101-1.585), respectively. For patients with pneumonia, PM_(2.5), PM_(10), and NO_2 exposures were risk factors for a poor prognosis. Exposure effects appeared to be greater during the warm season. Regulations focused on PM_(2.5), PM_(10), and NO_2 levels should be considered to improve patient outcomes.

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