運動對同半胱胺酸的可能效應

同半胱胺酸(homocysteine)是近年來被作為評估心血管疾病的指標之一，為人體必需胺基酸之甲硫胺酸(methionine)代謝過程的中間產物。當身體缺乏葉酸、維生素B12、B6常常會造成同半胱胺酸的升高，而同半胱胺酸升高後，主要會伴隨內皮細胞損害、血栓形成、氧化壓力及動脈粥狀硬化，以致引發心血管疾病。研究顯示，長期規律運動對肥胖者或高同半胱胺酸血症患者，可降低其同半胱胺酸，減少心血管疾病的風險，但對於同半胱胺酸安靜值界於正常範圍的健康者則影響有限。單次運動介入的研究結果則顯示，同半胱胺酸在小於1小時的運動後傾向不會改變；而單次長時間、高強度運動後，對體能水準較高或優秀的運動員同半胱胺酸亦不會有太大的變化，但對一般休閒者則容易引發其濃度立即上升，可能進而增加一般休閒者從事耐力運動後誘發心血管疾病的風險。

關鍵字

心血管疾病；甲硫胺酸；耐力運動；體能水準

並列摘要

In recent years, homocysteine is one of the biomarkers that used to assess the cardiovascular diseases. It is an intermediate in the metabolic pathway of the essential amino acid methionine. When the body is lack of folic acid, vitamin B12, or vitamin B6, it often results in elevation of the homocysteine. The elevated homocysteine mainly causes endothelial damage, venous thrombosis, oxidative stress and atherosclerosis, so that leads to cardiovascular diseases. Studies have shown that long-term regular exercise for obese persons or the persons who have homocysteinemia can reduce his/her homocysteine, and then reduce the risk of cardiovascular diseases. However, a limited influence is shown in healthy people whose homocysteine baseline is normal. The result of single bout post exercise reveals that the homocysteine would not change when people exercise less than one hour. It also shows no obvious change after long duration and high intensity exercise for higher physical fitness level people or elite athletes. But for normal people, it easily causes homocysteine to rise immediately, and then maybe increase the risk of cardiovascular diseases after engaging in endurance exercise.

並列關鍵字

Cardiovascular diseases ； Methionine ； Endurance exercise ； Fitness level

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運動對同半胱胺酸的可能效應

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