We reported the first case of lung herniation after cardiopulmonary resuscitation (CPR) with a mechanical chest compression device and a literature review. Older age, long CPR duration, mechanical ventilation, and rib fracture were risk factors. Subcutaneous emphysema was the most common manifestation and indication for further computed tomography to make a definite diagnosis. Despite its rarity, physicians should keep a high awareness of this possible fetal complication. Further studies comparing mechanical and manual CPR for the risk of lung herniation are warranted.
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