Title

醣類化合物之合成 1、2,5雙唾液酸之合成 2、利用歧化反應合成醣類化合物

Translated Titles

Synthesis of Glyco-Conjugates 1. Synthesis of 2,5-Neuraminic acid dimer 2. Synthesis of Glyco-Conjugates via Olefin Metathesis

DOI

10.6342/NTU.2004.00597

Authors

范綱廷

Key Words

唾液酸 ; 歧化反應 ; 醣類 ; neuraminic acid ; metathesis ; c-linked ; KRN7000 ; saccharide ; ceramide ; phytosphingosine

PublicationName

臺灣大學化學研究所學位論文

Volume or Term/Year and Month of Publication

2004年

Academic Degree Category

博士

Advisor

方俊民

Content Language

繁體中文

Chinese Abstract

本論文中,以探討不同類型醣類化合物的合成為主。在近年來,醣類化學逐漸受到重視,除了發現此類分子是細胞間作用的媒介之外,在藥物的開發上,也佔有很重要的地位。但在傳統的醣類合成上,受到反應條件嚴苛及選擇性的問題影響,以致許多含醣分子的合成較為困難,本論文即分別針對以醣類為主的數種化合物進行合成的改進。 在選擇的幾種醣類化合物中,有生物體內天然的醣類配位基,如海膽卵子表面的2,5聚唾液酸,此為受精作用中不可或缺的媒介,合成此2,5聚唾液酸利用一完全

English Abstract

In this thesis, new methods for the synthesis of several different types of glyco-conjugates were developed. The target including natural glyco-conjugated ligand, drug mimetic and derivatives. 2,5-neuraminic acid was chosen as the first target. This glycol-conjugate was a very important signal transductor during fertilization of the sea urchin. Here, an amide bond formation reaction was used to construct the 2,5-neuraminic acid dimer. By this method, glycosidic bond was formed through an exclusive

Topic Category 基礎與應用科學 > 化學
理學院 > 化學研究所
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