大氣電漿改質神經導管材料於周邊神經之應用

林哲永

doi:10.6845/NCHU.2007.00582

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大氣電漿改質神經導管材料於周邊神經之應用

The application of nerve conduits materials modified by atmospheric plasma treatment

林哲永 , Masters　　Advisor：徐善慧　　

繁體中文 DOI： 10.6845/NCHU.2007.00582

大氣電漿；接枝；微溝槽；納米金幾丁聚醣；聚乳酸；生長因子； Air plasma ； grafing ； microgroove ； gold nanocomposite ； chitosan ； PLA ； fibroblastic cell growth factor 1

Abstract │ Reference (40) │ Times Cited (2) │ Altmetrics

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In this study the bridgeable polylactide (PLA) substrate was fabricated with instructive microgrooves first, and then grafted with chitosan-Au nanocomposites (chi-Au) and fibroblast growth factor 1 (FGF1) by atmosphere air plasma treatment to modify the hydrophobic surface. The surface properties of modified substrates were characterized by scanning electron microscope (SEM) and electron spectroscopy for chemical analysis (ESCA). The results showed that the presence of chitosan and chi-Au were demonstrated on PLA surface by SEM and ESCA after atmosphere air plasma treatment. For in vitro studies, the degree of cell alignment and the proliferation of murine neural stem cells were evaluated. It was shown that the cell proliferation was significantly higher on the modified surface and the degree of cell alignment also increased from 84.3% to 89.5% at 72 hours. Furthermore, greater levels of gene expression for BDNF, GDNF and FGF1 and more FGF1 were absorbed on the air plasma modified chi-Au substrate. It is concluded from this study that the use of air plasma was a potential technique for surface modification of biomaterials.

Reference ( 40 ) 〈TOP〉

1. Evans GR. Challenges to nerve regeneration. Semin Surg Oncol (2000).
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2. Belkas, J. S., Shoichet, M. S. & Midha, R. Peripheral nerve regeneration through guidance tubes. Neurol. Res. 26, 151-160 (2004).
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3. Molander, H., Olsson, Y., Engkvist, O., Bowald, S. & Eriksson, I. Regeneration of peripheral nerve through a polyglactin tube. Muscle Nerve 5, 54-57 (1982).
連結：
4. Keeley, R. D., Nguyen, K. D., Stephanides, M. J., Padilla, J. & Rosen, J. M. The artificial nerve graft: a comparison of blended elastomer-hydrogel with polyglycolic acid conduits. J. Reconstr. Microsurg. 7, 93-100 (1991).
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5. Rosen, J. M., Padilla, J. A., Nguyen, K. D., Siedman, J. & Pham, H. N. Artificial nerve graft using glycolide trimethylene carbonate as a nerve conduit filled with collagen compared to sutured autograft in a rat model. J. Rehabil. Res. Dev. 29, 1-12 (1992).
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