Inhibition of crop productivity by salt stress is mainly due to its impact on crop growth. Cell wall is an important component of plant biomass. Salt stress inhibits growth through affecting cell wall loosening. Expansins are cell wall proteins that promote wall loosening. Thus, cell wall-related genes and expansins play roles in regulating salt stress tolerance. The present review summarizes the major research advances in elucidating the importance of cell wall-related genes and expansins in salt stress tolerance.