Milk Consumption Is a Risk Factor for Prostate Cancer in Western Countries: Evidence from Cohort Studies

牛奶消费与前列腺癌：西方国家列队研究的meta分析

Li-Qiang Qin ； Jia-Ying Xu ； Pei-Yu Wang ； Jian Tong ； Kazuhiko Hoshi

《Asia Pacific Journal of Clinical Nutrition》 16卷3期 (2007/09) Pp. 467-476

https://doi.org/10.6133/apjcn.2007.16.3.12

摘要

我们曾经利用meta分析研究了病例－对照研究，发现牛奶消费和前列腺癌发生存在正相关。本研究中，我们收集了1966年到2006年发表的队列研究，用meta分析的方法进一步研究牛奶及奶制品消费和前列腺癌之间的总相对危险度（RR）。我们共搜索到18篇相关文章，其中含有的13个独立研究被用于 本次分析。比较最高和最低消费组后得到总RR为1.13（95%可信区间=1.02-1.24）。经分层分析后仍存在正相关。单独分析研究对象被分成5个剂量组的队列研究则发现RR值随消费量的上升而增强。我们还评价了诸如奶制品分类、癌症分级和出版偏倚对meta分析的影响。本研究提示牛奶和奶制品消费增加了患前列腺癌的危险性。其机制可能与牛奶和奶制品中的脂肪、激素以及钙有关。

關鍵字

牛奶 ； 奶制品 ； 前列腺癌 ； meta分析 ； 队列研究

並列摘要

We have previously found a positive association between milk consumption and prostate cancer risk using metaanalysis to analyze published case-control studies. In the present study, further meta-analysis was conducted to estimate the summary relative risk (RR) between the consumption of milk and dairy products and prostate cancer from cohort studies published between 1966-2006. We found 18 relevant articles and 13 independent studies were available for our analysis. The summary RR was 1.13 (95% confidence interval = 1.02-1.24) when comparing the highest with the lowest quantile of consumption. The summary RRs by study stratification showed a positive association. A dose-response relationship was identified when combining the studies that partitioned the consumption by quintiles. We also evaluated the effects of some limitations, such as dairy classification, prostate cancer stages and publication bias, in the present study. These findings, together with the previous study, suggest that the consumption of milk and dairy products increases the risk of prostate cancer. This is biologically plausible since milk contains considerable amounts of fat, hormones, and calcium that are associated with prostate cancer risk.

並列關鍵字

milk ； dairy products ； prostate cancer ； meta-analysis ； cohort study ； oriental populations