- 期刊
- OpenAccess
Factors Associated with Circulating Soluble Vascular Cell Adhesion Molecule-1 Level in Hemodialysis Patients
摘要
BACKGROUND: Elevated circulating soluble vascular cell adhesion molecule-1 (sVCAM-1) predicts outcomes in chronic kidney disease. We aimed to assess the factors associated with sVCAM-1 in hemodialysis (HD). METHODS: In this cross-sectional study, we included 189 prevalent HD patients. Serum cell adhesion molecule and inflammatory cytokine levels were measured using an enzyme-linked immunosorbent assay. Circulating mononuclear cells (MNCs) were isolated from patients and used to measure superoxide production and endothelial adhesion. Ultraweak and luminal-enhanced chemiluminescence were used to estimate the superoxide generation by MNCs. MNC adhesiveness to endothelial cells was measured with an automatic fluorometer. RESULTS: In a univariate analysis, sVCAM-1 was significantly associated with age, MNC-endothelial cell adhesion, intercellular adhesion molecule 1 (ICAM-1), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), serum cholesterol, triglyceride, glucose, hemoglobin, albumin, E-selectin, MCP-1, tumor necrosis factor-α, and higher basal MNC superoxide production. Stepwise multivariate linear regression analysis showed that age, higher basal superoxide production, MNC-endothelial cell adhesion, soluble intercellular adhesion molecule-1 (sICAM-1), hs-CRP, and IL-6 were independently associated with sVCAM-1. Serum albumin was negatively associated with sVCAM-1. CONCLUSION: Along with some traditional prognostic factors including age, albumin, sICAM-1, hs-CRP, and IL-6, sVCAM-1 is strongly associated with two novel prognostic factors, basal MNC superoxide production and MNC-endothelial cell adhesion, in HD patients.
延伸閱讀
- 郭周斌、曾偉誠（2019）。Novel Approaches to Improve the Outcome of Hemodialysis Vascular Access。腎臟與透析，31(2)，77-81。https://doi.org/10.6340/KD.201906_31(2).0007
- 蔡蕙鍾、郭淑冠、郭慧如、黃慧芳、吳玉萍、郭麗雀、林麗君、王慧卿、李建德、黃惠勇（2021）。Application of Lean Methodology in the Management of Hemodialysis Arteriovenous Access Dysfunction。醫務管理期刊，22(3)，247-260。https://doi.org/10.6174/JHM.202109_22(3).247
- 石晟毓（2014）。Detection of Blood Leakage in Arteriovenous fistula during Hemodialysis〔碩士論文，國立臺北科技大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0006-2301201410314900
- 劉亮廷（2017）。Arteriovenous Fistula: The Most Common Vascular Access of Renal Disease Patients on Long-term Hemodialysis。北市醫學雜誌，14(4)，409-415。https://doi.org/10.6200/TCMJ.2017.14.4.01
- Yang, S. S., Lin, S. H., Tsai, W. S., Juang, J. G., & Lin, Y. F. (2002). Evaluation of Metabolic Acidosis in Chronic Hemodialysis Patients. Journal of Medical Sciences, 22(4), 165-169. https://www.airitilibrary.com/Article/Detail?DocID=10114564-200208-201305090025-201305090025-165-169