綜論生物製劑免疫療法在非癌症之應用

林世昌

doi:10.6320/FJM.201807_22(4).0004

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Health & Medical Care > General

DOI： 10.6320/FJM

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綜論生物製劑免疫療法在非癌症之應用

Overview of Biologics in Non-Cancer Immunotherapy

林世昌(Shih-Chang Lin)

台灣醫學； 22卷4期 (2018 / 07 / 25) ， P380 - 387

繁體中文 DOI： 10.6320/FJM.201807_22(4).0004

免疫疾病；生物製劑； T細胞； Th17細胞； B細胞； CD20 ； Intergrin ； IL-1 ； IL-4 ； IL-5 ； IL-6 ； IL-13 ； IL-17 ； IL-23 ； TNF-α ； immune diseases ； biological agent or biologic ； T cells ； Th17 cells ； B cells ； CD20 ； Intergrin ； IL-1 ； IL-4 ； IL-5 ； IL-6 ； IL-13 ； IL-17 ； IL-23 ； TNF-α

Abstract │ Reference (30) │ Altmetrics

Abstract 〈TOP〉

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The advances in clinical immunology research have provided a better understanding of the immunological pathogenesis of various immune diseases. Diverse immune cell types, cellular surface molecules and cytokines have been identified to be involved in the pathogenesis of different immune diseases and therefore can serve as the targets of immunotherapy with the use of various biologics. Likewise, the link between immune evasion and cancer occurrence leads to development of biologics for cancer immunotherapy recently. In this review, some characteristics of biologics are described. The pathogenesis for each of some human non-cancer immune diseases, including autoimmune, inflammatory and allergic diseases, is briefly discussed, focusing on T cell subsets, Th17 cells, B cells, some surface molecules (such as CD20 and intergrin), and some key inflammatory cytokines (such as IL-1, IL-4, IL-5, IL-6, IL-13, IL-17, IL-23 and TNF-α). Several biologics have been approved to treat different immune diseases, and their mechanistic basis of therapeutic target is reviewed here. The use of biologic therapies may be rapidly expanding in the future.

Reference ( 30 ) 〈TOP〉

Fujimoto K, Minami S, Yamamoto S, et al: Comparison of timing and decision-makers of do-not-resuscitate orders between thoracic cancer and non-cancer respiratory disease patients dying in a Japanese acute care hospital. Support Care Cancer 2014;22:1485-92. doi: 10.1007/s00520-013-2105-z
連結：
Au DH, Udris EM, Fihn SD, et al: Differences in health care utilization at the end of life among patients with chronic obstructive pulmonary disease and patients with lung cancer. Arch Intern Med 2006;166:326-31. doi: 10.1001/archinte.166.3.326
連結：
Goodridge D, Lawson J, Duggleby W, et al: Health care utilization of patients with chronic obstructive pulmonary disease and lung cancer in the last 12 months of life. Respir Med 2008;102:885-91. doi: 10.1016/j.rmed.2008.01.007
連結：
Nava S, Hill N: Non-invasive ventilation in acute respiratory failure. Lancet 2009；374:250-9. doi: 10.1016/S0140-6736(09)60496-7
連結：
黎瑞萍、陳乃釧、洪宗杰等：間歇性使用非侵襲性正壓呼吸器：一個案報告。安寧療護雜誌2008；13:484-93。[Li JP, Chen NC, Hung TC, et al: Intermittent Non-Invasive Positive Pressure Ventilater Support-A Case Report. Taiwan Journal of Hospice Palliative Care 2008;13: 484-93.] doi: 10.6843/NTHU.2009.00011
連結：

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