Bone cement augmentation of pedicle screw is an important surgical procedure for osteoporotic vertebral collapse, preventing screw loosening, migration or back-out. Bone cement leakage may develop and mostly does not compress the peripheral tissue of the vertebral body including the spinal cord. However, to our best knowledge, bone cement leakage into the inferior vena cava during cement augmentation of pedicle screws for osteoporotic vertebral collapse has been not reported in the literature. We reported an 84-year-old male with asymptomatic cement leakage into inferior vena cava during this procedure and the possible pathophysiological mechanism was also discussed.