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Adaptation of the Secretion of Gastric Acid and Gastric Inhibitory Peptide in Response to Propylthiouracil
並列摘要
The purpose of this study was designed to investigate the effects of the intravenous (IV) infusion of propylthiouracil (PTU) on basal and pentagastrin-stimulated gastric acid secretion (GAS), as well as plasma concentrations of gastric inhibitory polypeptide (GIP), and calcium (Ca(superscript 2+)). The polyethylene (PE) tubes were inserted into the esophagus, pylorus, right femoral and jugular veins as luminal and vascular exits respectively in adult male rats. Basal GAS was collected for 45 min before IV infusion of alkaline saline (2 ml/h, control group) or PTU (20 mg/ml/ 300 g BW, experimental group) for 45 min. Infusion of pentagastrin (8 μg/ml/300 g BW) was added for 90 min following infusion of alkaline saline or PTU for an additional 45 min. IV infusion of PTU increased the concentrations of plasma thyroid-stimulating hormone (TSH) and GIP but decreased the level of plasma Ca(superscript 2+) in male rats. Neither the basal nor the pentagastrin-evoked levels of gastric acid secretion were altered by the IV infusion of PTU. These results suggested that the unchanged gastric acid secretion in male rats after IV administration of PTU was at least in part due to an adaption of gastric acid secretion to PTU caused by increased release of GIP and decreased level of plasma calcium.
延伸閱讀
- Chang, H. R. (2007). Molecular Basis underlying Gating Mechanism and Pharmacological Modulation of the N-Methyl-D-Aspartate Receptor Channel [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2007.02206
- Liu, Y. H., Lu, Y. L., Han, C. H., & Hou, W. C. (2013). Inhibitory Activities of Acteoside, Isoacteoside, and Its Structural Constituents against Protein Glycation in Vitro. Botanical Studies, 54(), 31-39. https://doi.org/10.1186/1999-3110-54-6
- Liu, Y. C. (2013). Structure- and mechanism-based enzyme design for biologically active new chemical entities on glycopeptide antibiotics [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2013.11171
- Nga, B. T. T., Takeshita, Y., Yamamoto, M., & Yamamoto, Y. (2014). Studies of Inhibitory Mechanisms of Propeptide-Like Cysteine Protease Inhibitors. Enzyme Research, (2014), 250-259. https://doi.org/10.1155/2014/848937
- 劉宛欣（2010）。Analysis of anti-apoptotic factors induced by Helicobacter pylori infection of gastric epithelial cells〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2010.02976