Dimethylglycine(二甲基甘安酸DMG)對自閉症孩童的療效探析

A Double Blind Study of Dimethylglycine Treatment in Children with Autism

鄭信雄(Shin-Siung Jung) ； 李月卿(Yueh-Ching Lee)

《慈濟醫學雜誌》 12卷2期 (2000/06) Pp. 111-121

https://doi.org/10.6440/TZUCMJ.200006.0111

摘要

Objective: A double blind study of dimethylglycine (DNG)treatment in autistic children. Patients and Methods: The 106 autistic children were from an autism society and were matched into two groups according to sex, age, body weight, and language ability, and were randomly assigned to an experimental group taking DNG or a control group taking a placebo, with identical packaging in both groups. DNG dosage was equivalent to 6.94 mg to 10.41 mg per kilogram body weight. It was taken for 4 weeks, followed by a 2 week free interval for washout of DNG effect. Than for another 4 weeks the groups crossed over to the alternate treatment. An Abnormal Behavior Checklist (ABC), Week-data, and Toni-2 were used for assessment. At the end of the first 4 weeks 22 cases (21%) were lost. At the end of 10weeks 61 cases (58%) were lost which was inadequate for analysis. Therefore we decided to use the data from the first 4 weeks for our main analysis. Results: The scores of autism in experimental (DNG) group was found to be signify-cantly better than in the placebo-control group according to MANOVA assessment. Improvement was 78% in total and was observed in all fields of ABC subscales on paired T-test. About 7% of patients had side-effects, mainly insomnia and irritability, 78% of which could be overcome with folic. High suggestibility and diversity in symptoms of autism were observed in both the experimental and placebo-control groups and this may cause difficulty in assessment. Conclusion: This research showed short time and mild to moderate effectiveness of DNG treatment in children with autusm in irritability, lethargy, stereotype, hyperactivity, and inappropriate speech. Research of DNG in long time effect to autism is indicated. (Tzu Chi Med J 2000; 12:111-121)

關鍵字

自閉症 ； Dimethylglycine ； 維他命B15 ； Pangamic Acid

並列摘要

Objective: A double blind study of dimethylglycine (DNG)treatment in autistic children. Patients and Methods: The 106 autistic children were from an autism society and were matched into two groups according to sex, age, body weight, and language ability, and were randomly assigned to an experimental group taking DNG or a control group taking a placebo, with identical packaging in both groups. DNG dosage was equivalent to 6.94 mg to 10.41 mg per kilogram body weight. It was taken for 4 weeks, followed by a 2 week free interval for washout of DNG effect. Than for another 4 weeks the groups crossed over to the alternate treatment. An Abnormal Behavior Checklist (ABC), Week-data, and Toni-2 were used for assessment. At the end of the first 4 weeks 22 cases (21%) were lost. At the end of 10weeks 61 cases (58%) were lost which was inadequate for analysis. Therefore we decided to use the data from the first 4 weeks for our main analysis. Results: The scores of autism in experimental (DNG) group was found to be signify-cantly better than in the placebo-control group according to MANOVA assessment. Improvement was 78% in total and was observed in all fields of ABC subscales on paired T-test. About 7% of patients had side-effects, mainly insomnia and irritability, 78% of which could be overcome with folic. High suggestibility and diversity in symptoms of autism were observed in both the experimental and placebo-control groups and this may cause difficulty in assessment. Conclusion: This research showed short time and mild to moderate effectiveness of DNG treatment in children with autusm in irritability, lethargy, stereotype, hyperactivity, and inappropriate speech. Research of DNG in long time effect to autism is indicated. (Tzu Chi Med J 2000; 12:111-121)

並列關鍵字

autism ； Dimtehylglycine ； vitamin B15 ； Pangamic Acid