The concept of fast-track surgery was implemented in clinical practice on the basis of recent investigations in perioperative pathophysiology and care, enabling elimination of some procedures that are not justified in the review of evidence-based medicine. The primary objective of this approach is to hasten recovery, decrease morbidity, and shorten hospitalization after major surgical procedures. Key elements involve preoperative patient information, minimizing fasting, nonroutine use of mechanical bowel preparation, nasogastric tube and abdominal drains, regional anesthesia, prophylaxis of venous thrombosis, avoid fluid overload and hypothermia during operation, early catheter removal, opioid-sparing analgesia, early feeding and mobilization. The novel concept of fast-track surgery appears to be beneficial in patients operated for gynecologic malignancy, as hospital stay and medical morbidity are reduced.