A 68-year-old female with sudden-onset chest pain was suspected of having acute myocardial infarction and admitted to our hospital. She had a history of diabetes mellitus, lung cancer, and transitional cell carcinoma. We treated her by performing percutaneous coronary intervention. However, hypotension with unstable hemodynamic parameters persisted. Ventricular septal rupture was identified by echocardiography. Her family refused surgical repair of the ventricular defect, and subsequently she died from cardiogenic shock.