Using a purposive sampling scheme 60 nurses having been caring for drug addicted clients for more than two months were included in this study. Structured questionnaires were used for investigating their job stress and coping behaviors. Data were analyzed by SAS/PC. Statistics methods used included frequency, percentage, mean and standard deviation of descriptive statistics, t-test, ANOVA, Pearson correlation and general linear model analysis. The results reveals that the degree of nurses' job stress lies between mild to moderate, among which the main stressor was derived from nursing care of clients. It is also found that the degree of stress perception was significantly different with various types of ward (p=＜.025). The coping behaviors of the nurses was classified into three strategies: initiative, medium and passive. The initiative strategy was problem-solving oriented which was commonly used by the nurses, and was negatively related to the working experiences (r=-0.30, p＜.05). The use of medium strategy was related to marriage status of nurses (t(58)=-2.04, p＜.05). Besides, whether nurses adopt passive strategy to cope with their work pressure was affected by professional training (partial correlation r=.30, p＜.05). Hence, there is a close relationship between the pressure that the nurses bear, and the reflective behaviors they adopt.