Study of the Synthetic Utility of Tebbe Reagent

泰柏試劑在合成上用途之探討

周大紓(Ta-Shue Chou) ； 黃松本(Sung-Ben Huang)

《中央研究院化學研究所集刊》 31期 (1984/03) Pp. 41-44

https://doi.org/10.6522/BICAS.1984.31.6

摘要

泰柏試劑與多種醯氯化合物反應，可生成相應的甲基酮。此反應的一種重要中間體為此甲基酮的烯醇鈦鹽。由於鈦鹽不安定無法確定其存在，故以數種間接證據支持其為中間體，其用做直接烷化的用途在文中加以探討。

並列摘要

The reaction between acyl chlorides and Tebbe reagent 1 gave the corresponding methyl ketones. Titanium enolates of the metbyl ketones were believed to be the key intermediates. Although the enolate intermediates were very unstable and thus not detected, several experimental facts strongly supported their existence. The utility of the useful intermediates in direct alkylation is discussed.