- 期刊
Humoral and Cellular Immunity in Asthmatic Children-Ⅰ. Immunogiobulin G, A and M in Asthmatic Children
氣喘病兒之體液性及細胞性免疫力之研究－Ⅰ.氣喘病兒血清免疫球蛋白G，A及M濃度之研究
摘要
著者應用從Hyland公司購買之Immunoplates以定量132位外因性（過敏型）及12位內因性（感染型）氣喘病兒之血清免疫球蛋白IgG，IgA及IgM之濃度，以評價氣喘病兒之體液性免疫力之情況。 外因性氣喘病之診斷標凖爲病人需具有下列4種特點中之兩種以種以上者。4種特點包括：個人或家族過敏病史，周邊血液像有嗜伊紅性白血球增加，血清免疫球蛋白E增加及陽性之過敏原皮膚試驗。 病兒免疫球蛋白之濃度若低於同年齡正常兒童之平均值減去2標凖誤差後之值時，即認爲有降低之情形。 研究結果發現，外因性氣喘病兒中有13名(9.8%) IgG降低，有1名(0.75%) IgA降低；內因性病兒中，有1名(8.3%) IgG降低，1名(8.3%) IgA降低，另1名(8.3%) IgG及IgA兩者同時降低。 15名IgG降低之病兒之血清IgG值介於480-710mg%之間；3名IgA降低之病兒之血清IgA值介於27-29mg%之間。而在此低血清免疫球蛋白之濃度範圍內，免疫球蛋白濃度和氣喘病兒之氣喘嚴重度和感染髮生頻率沒有關係。
關鍵字
無資料並列摘要
By using commercially available immunoplates (Hyland Laboratories), the serum concentrations of immunoglobulins, IgG, IgA and 1gM were determined in 132 children with extrinsic asthma and in 12 children with intrinsic asthma. The immunoglobulin level was considered to be low if the value was below the mean minus two standard deviations. In patients with extrinsic asthma, IgG was low in 13 (9.8%), and IgA was low in 1 (0.75%); in Patients with intrinsic asthma, IgG was low in 1 (8.3%), IgA was low in 1 (8.3%), and IgG and IgA were low concomitantly in 1 (8.3%). In this series, the lowest level for IgG was 480 mg% and for IgA 27mg%. There was no correlation between the severity of asthma and serum immunoglobulin levels.