- 期刊
Oxytocin and Neonatal Hyperbilirubinemia
催生素和新生兒高血膽紅素症之研究
摘要
A prospective study of 104 cases showed labor with oxytocin infusion induces a higher incidence of neonatal hyperbilirubinemia. We defined hyperbilirubinemia as a total serum bilirubin level above l5mg%. The incidence of hyperbilirubinemia in intravenous oxytocin infusion group (18 out of 32 cases, 56%) is higher than the control group (9 out of 52 cases, 17%), P＜0.001. In the intramuscular oxytocin group it is 7 (35%) out of 20 and there is no significant difference compared with the control group. We also took an RBC count on the first day of life. The mean figure for the three groups was as follows: Intravenous group, 615±140×10^4/mm^3; Intramuscular group, 574±174×10^4/mm^3; Control group, 568±148×10^4/mm^3. We found the RBC count in the intravenous group to be considerably higher than in the control group (P＜0.01). It was only slightly higher in the intramuscular group and no significant difference between intramuscular and the control group. It is suggested that the large number of hyperbilirubinemia cases in the intravenous infusion group is correlated with the higher RBC count. There was no evidence of hypoxia during labor or that the chemical effect of oxytocin induces neonatal hyperbilirubinemia.
關鍵字
無資料並列摘要
A prospective study of 104 cases showed labor with oxytocin infusion induces a higher incidence of neonatal hyperbilirubinemia. We defined hyperbilirubinemia as a total serum bilirubin level above l5mg%. The incidence of hyperbilirubinemia in intravenous oxytocin infusion group (18 out of 32 cases, 56%) is higher than the control group (9 out of 52 cases, 17%), P＜0.001. In the intramuscular oxytocin group it is 7 (35%) out of 20 and there is no significant difference compared with the control group. We also took an RBC count on the first day of life. The mean figure for the three groups was as follows: Intravenous group, 615±140×10^4/mm^3; Intramuscular group, 574±174×10^4/mm^3; Control group, 568±148×10^4/mm^3. We found the RBC count in the intravenous group to be considerably higher than in the control group (P＜0.01). It was only slightly higher in the intramuscular group and no significant difference between intramuscular and the control group. It is suggested that the large number of hyperbilirubinemia cases in the intravenous infusion group is correlated with the higher RBC count. There was no evidence of hypoxia during labor or that the chemical effect of oxytocin induces neonatal hyperbilirubinemia.