- 期刊
果糖對於幼兒腹瀉的臨床療效
Beneficial Effect of Fructose in the Treatment of Pediatric Patients with Diarrhea
摘要
口服蔗糖可以增加蔗糖酵素及參芽糖酵素之活性，1是己被承認的事實。但對於因腹瀉導致蔗糖不耐受性之病兒而言，口服蔗糖無法被小腸消化、吸收、更遑論其刺激酵素活性的能力了。 馬偕醫院小兒科，自民國72年6月至73年1月共為100名腹瀉病兒做蔗糖耐受性測驗。其值低於對照組（10名因其他疾病住院，無腹瀉之病兒）的67例中，有42例（A組）接受5%果糖3gm/kg/day，一天四次，連續給4~5天；另2例（B組）則沒有給果糖。結果在4~5天後，A組接受蔗糖耐受性測驗追綜檢查的25例中，有18例進步；B組接受追綜檢查的8例中僅有2例進步(P=0.026)。臨床上觀察共腹瀉進步情形，蔗糖不耐受性的病人(△＜50mg/dl)且飲用Pregestimil的29例中，給果糖而有進步的為13/19，不給果糖而有進步的為3/10 (P=0.0078)；△＞50mg/dl以上者和飲用Isomil之病例，則是否給與果糖，對其腹瀉進步情況，並無統計學上差異。我們的結論是：果糖具有與蔗糖同樣的效果，可以使病人增加對蔗糖之耐受性，對那些因腹瀉引發蔗糖不耐受性的病人，具有臨床療效。
關鍵字
無資料並列摘要
Sucrose has been known to increase jejunal sucrase-isomaltase activities, but may worsen diarrhea in cases of sucrose intolerance. One hundred sucrose tolerance tests (STT) were performed in the pediatric department at Mackay Memorial Hospital from June 1983 to January 1984. Sixty seven diarrhea cases has STT data lower than that of ten controls. Five percent fructose, 3 gm/kg/day, qid was given for 4-5 days to 42 patients (Group A), and no fructose was given to another 25 patients (Group B). Repeated STT on 25 cases from Group A and 8 from Group B showed that 18/25 in Group A had improvement on second testing, compared with 2/8 in Group B (P=O.026, Fisher's exact test). Clinically, pregestimil was fed to 29 cases who exhibited sucrose intolerance. Fructose was given to 19 patients while no fructose was given to another 10 patients. Diarrhea improved in 13/19 in the former group, compared with 3/10 in the latter group (P=0.0078). In conclusion, oral fructose seems to be able not only to increase tolerance to sucrose, but also has a beneficial effect in reducing diarrhea in patients with sucrose intolerance.