- 期刊
Clinical Observation of Primary Epstein-Barr Virus Infection in Children
兒童原發性Epstein－Barr病毒感染之臨床觀察
摘要
本研究是以病歷回顧的方式探討馬偕醫院小兒科過去一年中有42位（13天到14歲），用間接免疫瑩光檢驗顯示抗Epstein-Barr病毒Capsid抗原免疫球蛋白M陽性的病例。 季節上是以晚春和初秋的發生率較高。男性居多，2/3病患年齡在2歲和5歲之間。男女年齡相比並無差異。4歲以下的病兒顯現較多的脾腫，而4歲以上則多喉痛、肝腫和皮疹。臨床表徵發生頻度依次為發燒、淋巴病變、肝腫、滲出性扁桃腺炎。1/3病人肝功能不正常。送檢的血清（25例）都沒有嗜異性抗體(heterophil antibody)。所有血清樣本都是在發病後2週內採取，其中有4例其抗Epstesn-Barr病毒Capsid抗原免疫球蛋白G力價達320，而所有檢驗（23例）力價的幾何平均是60。罹患感染性單核球增多症(infectious mononucleosis)的小孩佔全部原發性感染的60%，都完全痊癒。2例懷疑子宮內感染，其中l例死於敗血症。伴隨神經病變的5例仍須在門診繼續追蹤和治療。
關鍵字
無資料並列摘要
The charts of forty-two patients, ranging in age from 3 days to 14 years, who had positive anti-Epstein-Barr virus-capsid-antigen IgM antibody were studied. There were two seasonal peaks: one in late spring and the other, in late autumn. Males predominated. Two-Thirds of the patients were 2 to 5 year-old. No age difference was detected between the sexes. While the group that was younger than 4 years old experienced more splenomegaly, the rashes. One third of the patients suffered from abnormal liver function. Heterophil antibody was negative in all 25 patients testd. While the geometric mean titer of anti Epstein-Barr virus-capsid-antigen IgG in 23 cases was 60, a titer of 1:320 was found in 4 cases. All were sampled within two weeks of the onset of the illness. Cases presented with the manifestation of mononucleosis stood for 60% of the total cases. Two cases were suspected of having intrauterine infections, and one patient died of sepsis. Five cases with neurologic complications still required follow-up in the outpatient clinic.