- 期刊
Seroepidemiological Study of Epstein-barr Virus Infection in Children in Taipei
臺北地區兒童EB病毒感染之血清流行病學研究
摘要
在民國73年6月至10月間，本研究針對臺北地區15歲以下不同年齡層健康孩童作血清樣本的採集，主旨在調查臺北地區孩童受EB病毒感染的情形。我們共採取1350位孩童血清樣本包括723位男童與627位女童，以間接免疫螢光抗體法測定血清中對抗EB病毒外殼抗原(Viral Capsid Antigen VCA) IgG抗體力價。抗體力價大於1:10者視為陽性反應，並以此計算各年齡層感染的盛行率。結果顯示血清抗體陽性盛行率在六個月以下的幼童，約為38.4%，而盛行率在六個月至一歲間更降低至只有6.4%。一歲以後，盛行率快速升高，二歲時期已達74.1%。此後盛行率持續得升高，而在四歲以後的孩童，其血清已有百分之九十以上呈現抗體陽性反應。10歲後更高達98%。 進一步分析一歲以下孩童血清抗體的陽性率，可見其由出生後兩個月內的60.6%, 逐月下降，在六個月至八個月間全無抗體表現，而後再逐漸有抗體出現。我們相信這時期抗體源自母體的抗體。從抗體力價的分佈由二歲以前主要為低力價轉變至二歲以後高力價居多的變化和幾何平均力價在一歲至三歲間的陡升顯示臺北地區孩童在孩童早期，尤其一歲至四歲間，已大部分受EB病毒的感染。至於男女性別對盛行率表現的影響，統計上沒有差別。
關鍵字
無資料並列摘要
Serum IgG antibody titer against viral capsid antigen (VCA) of Epstein-Barr virus (EBV) was measured by indirect immunofluorescence antibody method in 1350 children under 15 years of age, 723 males and 627 females, who were living in the Taipei area. Sera were collected from June through October 1984. Under the age of 6 months, the prevalence rate of positive serum VCA antibody was 38.4%. It decreased to 6.4% between 6 and 12 months of age, but rose to 65.8% during the second year of life. The rate continued to increase from 1 to 4 years of age, with a steep rise of geometric mean titer in the same period. The prevalence rate stayed at more than 90% after 4 years of age. From our data, it is obvious that most children in the Taipei area had been infected by EBV in early childhood, especially from 1 to 4 years of age.