- 期刊
Clover-Leaf Nucleus of Atypical Lymphocytes in CMV-Mononucleosis Syndrome: Report of One Case
巨細胞病毒單核球症所見之四葉苜蓿形細胞核非典型淋巴球：一病例報告
摘要
具有四葉苜蓿形細胞核的非典型淋巴球是一種在成人T－細胞白血病常見的白血球。偶爾，也可以在放置過久的血液樣品中見到。文獻中記載有此種白血球出現的病原有EB病毒及HIV病毒，但是從未曾報告CMV所引起的感染性單核細胞增多症也可以出現此種白血球。我們報告一例37天大的女嬰，她因為慢性腹瀉，貧血及體重增加遲緩而由外院轉介到本院。理學檢查上發現有肝脾腫大，實驗室檢查發現溶血性合併缺鐵性貧血，輕度血便，代謝性酸血症，肝臟酵素5倍上升。血液抹片中的白血球90%為單核球，而其中非典型淋巴球具有四葉苜蓿狀細胞核的便佔50%以上。病嬰的CMV-IgM (+)，CMV-IgG為1:16倍(+)，尿液的病毒培養出現CMV病毒，因此診斷為CMV引起的感染性單核細胞增多症，病嬰在住院兩天並輸血後在父母堅持下帶回家，出院兩週後回到門診追蹤時已不再有腹瀉及貧血，但是肝臟及脾臟仍然有腫大現象，本例證實CMV是引起四葉苜蓿形細胞核非典型淋巴球的另一個可能原因。
關鍵字
無資料並列摘要
Atypical lymphocytes with clover leaf nucleus are a frequent finding in adult type T-cell leukemia, and are occasionally seen in an overnight blood sample. This type of cell has apparently never previously been reported in cytomegaloviral infection. The case of a thirty-seven-day-old female infant presented with cytomegalovirus induced mononucleosis syndrome; her blood smear revealed atypical lymphocytes with clover leaf nucleus.