- 期刊
The Effect of Hypoallergenic Formula on the Occurrence of Allergic Diseases in High Risk Infants
餵食低過敏奶粉對高過敏傾向嬰兒發生過敏病之影響
摘要
33位有明顯家族過敏傾向且足月產的新生兒接受這項有關餵食過敏奶粉對過敏病發生率的影響的研究。這些新生兒被分成兩組，而這兩組的家族過敏分數和臍帶血血清IgE抗體並無顯著差異。甲組嬰兒餵食一般奶粉，共有18位；而乙組嬰兒從出生至6個月大均餵食母奶或低過敏奶粉，一共有15位。在一年的臨床追蹤中，我們觀察過敏病（異位性皮膚炎，過敏性鼻炎或氣喘）的發生，並且定期抽血檢驗其血清IgE抗體和牛奶、蛋等特異抗體。結果顯示，就高家族過敏傾向嬰兒而言：l)餵食一般奶粉有較高比例中度至重度異位性皮膚炎(39% vs 13%)與過敏性鼻炎(33% vs 13%)但是統計上並沒有意義。2)臍血IgE抗體與家族過敏分數無關。3)臍血IgE抗體或家族過敏分數的高低對一年內過敏病發生率沒有影響。4)低過敏奶粉(NAN. HA)可提供正常發育和營養且接受性良好。結論是：高家族過敏傾向的嬰兒，若餵食低過敏奶粉，在出生的頭一年，其皮膚過敏似較輕微，且過敏性鼻炎發生率較低。但是我們需要更多的嬰兒和更久的追蹤，才能獲得確定結論。
關鍵字
無資料並列摘要
To study the influence of hypoallergenic milk on the occurrence of allergic diseases, thirty-three high risk, normal full-term newborns were divided into two groups with comparable family allergy score (FAS) and cord serum IgE. Group A consisted of 18 babies fed since birth with regular formula, while group B included 15 babies fed breast milk and/or NAN H.A. (Hypoallergenic infant formula) for the first 6 months of life. Close clinical observations for the appearance of atopic dermatitis, allergic rhinitis and wheezing as well as serial examination of total serum IgE and milk-specific IgE antibodies were done during the first year of life. The results showed: 1) Infants fed regular formula had a higher incidence of moderate to severe atopic dermatitis (AD) and allergic rhinitis (AR) than those fed NAN H.A. (39% vs 13% for AD; and 33% vs 13% for AR), but the difference was not significant. There was no difference in the incidence of wheezing between these two groups; 2) There was no relationship between cord blood IgE and FAS; 3) Neither the cord blood IgE nor FAS influenced the occurrence of allergic diseases and total serum IgE at one year of age; 4) Hypo allergenic milk (NAN H.A.) could support normal growth and development. In conclusion, a higher incidence of moderate to severe AD and AR was found in high risk infants fed regular formula than in those fed hypoallergenic milk. However, a study with a larger number of babies and a longer period of follow-up is needed to obtain a solid conclusion.