- 期刊
The 30-Minute (1-24) ACTH Test for Evaluation of Adrenocortical Function in Childhood
30分鐘腎上皮促素試驗於孩童腎上腺皮質功能評估之應用
摘要
本研究共收集28位正常兒童及2位腎上腺機能不全的患童接受腎上皮促素試驗。除了一位艾迪森氏病患童僅接受腎上皮促素試驗外，其餘29位孩童均同時接受腎上皮促素試驗及胰島素低血糖試驗。兩位腎上腺機能不全的患童於接受腎上皮促素靜注後，血清中皮質醇的反應均低於正常範圍。於腎上皮促素靜注三十分後血清皮質醇的濃度與胰島素低血糖試驗中血清皮質醇的最大值之間的差異，在統計上並無意義；此二者之間亦無統計上有意義的相關。本研究中無一孩童對腎上皮促素有任何不良反應。本研究顯示對於孩童腎上腺皮質功能的評估，30分鐘腎上皮促素試驗不失為一簡單、安全且有臨床應用價值的篩檢方法。
關鍵字
無資料並列摘要
Twenty-eight children with normal adrenocortical function and two patients with adrenocortical insufficiency were enrolled in the present study. The ACTH test was performed in these 30 children, and the insulin hypoglycemia test was also performed for the same group, except for one with Addison's disease. Serum cortisol response after intravenous administration of (1-24) ACTH was below normal range in two patients with adrenocortical insufficiency. Neither significant correlation nor statistically significant difference was found between the serum cortisol level 30 minutes after (1-24) ACTH and the peak cortisol value during the insulin hypoglycemia test. None of these children had any adverse reaction to ACTH test. This study suggests that the 30- minute (1-24) ACTH test is a simple, safe and valuable screening procedure for evaluation of adrenocortical function in children.