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Comparative Evaluation of Antioxidant and Anti-Inflammatory Activities of Water Extracts from Major Taiwanese Mesona chinensis Cultivars
臺灣主要仙草品種水萃物之抗氧化與抗發炎活性比較
Abstracts
Mesona chinensis Benth. water extracts (MWE) have traditionally been used in Taiwan for health-promoting purposes, yet the comparative bioactivities of major cultivars remain unclear. This study examined four representative cultivars: 'Taoyuan No. 1' ('TY1'), 'Taoyuan No. 2' ('TY2'), 'TARI No. 1' ('TN1'), and 'Shuishang' ('SS'), to compare their total phenolic content (TPC), total flavonoid content (TFC), antioxidant capacity, and anti-inflammatory effects. Among them, 'TY2' exhibited the highest TPC, TFC, and antioxidant capacity, followed by 'TY1', whereas 'TN1' and 'SS' showed lower levels. All water extracts were non-cytotoxic to RAW264.7 macrophages at concentrations up to 500 μg mL^(-1) and slightly enhanced cell viability. All cultivars significantly suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production, and the degree of inhibition roughly corresponded with their antioxidant capacity. In contrast, TNF-α and IL-6 levels were not significantly affected, and mild elevations were observed in some cultivars. Collectively, these findings demonstrate that MWE possess NO-suppressing anti-inflammatory potential. This study provides a comparative framework for identifying cultivars with superior functional characteristics and future value in functional food development.
Parallel abstracts
仙草（Mesona chinensis Benth.）水萃物傳統上具有保健功效，但針對臺灣主要品種的抗氧化與抗發炎活性尚缺乏系統性比較。本研究評估4個仙草品種：「桃園1號」（'TY1'）、「桃園2號」（'TY2'）、「農試1號」（'TN1'）及「水上種」（'SS'）的總酚含量（total phenolic content; TPC）、總黃酮含量（total flavonoid content; TFC）、抗氧化能力以及抗發炎活性。結果顯示，'TY2'的TPC、TFC及抗氧化力最高，其次為'TY1'，而'TN1'與'SS'較低。所有水萃物在RAW264.7巨噬細胞中於500 μg mL^(-1)以下均無細胞毒性，甚至略微提升細胞活性。所有品種均顯著抑制脂多醣誘導的一氧化氮生成，且抑制強度大致與抗氧化力相關。相比之下，腫瘤壞死因子α與介白素-6生成並未被仙草水萃物明顯抑制，部分品種（'TN1'與'SS'）甚至促進其分泌。整體而言，仙草水萃物具有抑制一氧化氮的抗發炎活性。本研究為篩選具最佳抗氧化及抗發炎潛力的仙草品種提供了比較框架。