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Gypenosides Induce Apoptosis on Human Hepatoma Cells Line



絞股藍皀苷對人類肝癌細胞(Huh 7)的作用研究,結果顯示絞股藍皂苷具劑量依賴性的抑制肝癌細胞的繁殖與生存;於治療兩天時,肝癌細胞的DNA染色能力減少而形成亞G1的山峰,在A0區的細胞數增加,將通常的S期移轉至最終的S期(D1區),絞股藍皂苷並能導致DNA斷裂成呈階梯狀,這表示絞股藍皂苷誘導肝癌細胞的死亡是經由凋亡而來,細胞的凋亡本文也由形態學的研究證明。

Parallel abstracts

The effect of Gypenosides, an active component of Chinese herbs Gynostemma Pentaphyllum (Thumb) Makino, on human hepatoma cell line (Huh 7) was investigated. Results demonstrated that Gypenosides inhibited the proliferation or viability of the Huh 7 cells in a dose-dependent manner. The Huh 7 cells treated with Gypenosides for two days caused a less DNA stainable and formed sub-G1 peak, increased the cell numbers in the A0 region, shifted the ordinary S phase to the last S phase (D1 region) and induced a ladder pattern of fragmented DNA about 200 base pairs. It suggest that the cell death of hepatoma cells line Huh 7 induced by Gypenosides were via apoptosis, which was also confirmed by the morphological study.

Cited by

陳乃鳳(2011)。Part I 木樨草素加強太平洋紫杉醇誘導人類乳癌細胞凋亡之研究 Part II 桑白皮素抑制人類肝癌細胞入侵性生長之研究〔碩士論文,中山醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0003-0208201111095400