- 期刊
Ceftiofur等藥劑對豬之Pasteurella multocida肺炎生體內之治療效果
Therapeutic Effect in Vivo of Ceftiofur against Pasteurella Multocida Pneumonia in Pigs
摘要
Seeking the optimal chemotherapeutic drugs for effectively treating Pasteurella multocida pneumonia in pigs is of relevant concern. In this study, several commercial drugs were selected and trials were conducted for the evaluation of the efficacy in experimentally induced Pasteurella infection. Experimental results revealed that ceftiofur (Naxcel) was the most effective one when drug treatments were followed by intratracheal inoculation with 4x10^9 serotype A and 1x10^9 serotype D of P. multocida organisms. Whereas if the treatments were followed by the inoculation with 8x10^9 P. multocida organisms of serotype A and 2,560 hemolytic units of crude Actinobacillus pleuropneumoniae cytotoxin, both enrofloxacin and ceftiofur proved effective in alleviating pneumonic lesions and eliminating the inoculated bacteria. Other drugs, such as tylosin and oxytetracycline, exhibited no therapeutic effect. We can conclude that both ceftiofur and enrofloxacin are effective for treating P. multocida pneumonia in pigs.
並列摘要
Seeking the optimal chemotherapeutic drugs for effectively treating Pasteurella multocida pneumonia in pigs is of relevant concern. In this study, several commercial drugs were selected and trials were conducted for the evaluation of the efficacy in experimentally induced Pasteurella infection. Experimental results revealed that ceftiofur (Naxcel) was the most effective one when drug treatments were followed by intratracheal inoculation with 4x10^9 serotype A and 1x10^9 serotype D of P. multocida organisms. Whereas if the treatments were followed by the inoculation with 8x10^9 P. multocida organisms of serotype A and 2,560 hemolytic units of crude Actinobacillus pleuropneumoniae cytotoxin, both enrofloxacin and ceftiofur proved effective in alleviating pneumonic lesions and eliminating the inoculated bacteria. Other drugs, such as tylosin and oxytetracycline, exhibited no therapeutic effect. We can conclude that both ceftiofur and enrofloxacin are effective for treating P. multocida pneumonia in pigs.