- 期刊
Effect of the Age Factor on the Kinetics of Glycosylated Hemoglobin in Diabetic Rats
年齡因素對於糖尿病大白鼠醣化血色素動力學變化之影響
摘要
This study was designed to examine the appearance and sustained kinetics of glycosylated hemoglobin in diabetic rats. Three groups of rats of various ages were used: Group A: three months; Group B: six months, Group C: twelve months. The study was conducted during the 16-week period following a single-dose alloxan treatment to induce diabetes. Fasting serum glucose (FSG) levels were measured at the third day and then weekly after hyperglycemia was indicated. Glycosylated hemoglobin (G-Hb) levels were measured bi-weekly using the Helena G-Hb Quik Column method. Four weeks after the rats were treated with alloxan, results indicated a significant statistical correlation (r = 0.83, p＜0.05) between FSG and G-Hb levels. However, because the experimental diabetes had been established for longer than twelve weeks, FSG and G-Hb levels stabilized and revealed no correlation. After the alloxan treatment, G-Hb kinetic levels elevated linearly within six weeks. The rate of G-Hb synthesis in Group C (b = 1.36) was elevated more sharply than that of Group A (b = 0.31) or Group B (b = 0.60), and there was a significant statistical difference between Group A and Group C (calculated t = 3.0710; t .95(4) =2.776, p＜0.05). These results indicate that an age is an important factor influencing the kinetics of glycosylated hemoglobin in diabetic rats.
關鍵字
無資料並列摘要
This study was designed to examine the appearance and sustained kinetics of glycosylated hemoglobin in diabetic rats. Three groups of rats of various ages were used: Group A: three months; Group B: six months, Group C: twelve months. The study was conducted during the 16-week period following a single-dose alloxan treatment to induce diabetes. Fasting serum glucose (FSG) levels were measured at the third day and then weekly after hyperglycemia was indicated. Glycosylated hemoglobin (G-Hb) levels were measured bi-weekly using the Helena G-Hb Quik Column method. Four weeks after the rats were treated with alloxan, results indicated a significant statistical correlation (r = 0.83, p＜0.05) between FSG and G-Hb levels. However, because the experimental diabetes had been established for longer than twelve weeks, FSG and G-Hb levels stabilized and revealed no correlation. After the alloxan treatment, G-Hb kinetic levels elevated linearly within six weeks. The rate of G-Hb synthesis in Group C (b = 1.36) was elevated more sharply than that of Group A (b = 0.31) or Group B (b = 0.60), and there was a significant statistical difference between Group A and Group C (calculated t = 3.0710; t .95(4) =2.776, p＜0.05). These results indicate that an age is an important factor influencing the kinetics of glycosylated hemoglobin in diabetic rats.