- 期刊
酸化戊二醛與鹼化戊二醛的滅菌效果之比較
Comparison of the Bactericidal Effects of Acid Glutaraldehyde and Alkaline Glutaraldehyde
摘要
比較兩種戊二醛類：酸化戊二醛（®衛必殺，sonacide）及鹼化戊二醛（®適滴，cidex）在不同濃度，不同時間，對不同數量器械的滅菌效果及對器械的腐蝕性。結果發現器械浸泡於2%的酸化戊二醛和鹼化戊二醛溶液下20分鐘均可達到完全的滅菌效果，而0.1%酸化戊二醛浸泡30分鐘即可達到0.5%鹼化戊二醛泡30分鐘的效果，使得測試物的細箘殘存率低於2.9%以下。測試物泡於2%鹼化戊二醛內一個月後仍有0.5%的細菌殘存率，而浸泡於2%酸化戊二醛內一個月後則可完全滅菌。若將此兩種消毒液放置一個月後，浸泡測試物30分鐘，結果酸化戊二醛仍保有完全滅菌的能力，但鹼化二醛則還有11.4%~26.9%的細菌殘存率。兩種消毒液浸泡金屬器械14天後，對金屬器械重量及外觀皆沒有影響，但對橡膠或塑膠類則會使之變黃、變硬。結論是這兩種戊二醛類都能有效的殺滅細菌，所不同的是酸化戊二醛類拿出來使用後放置一個月仍保有完全滅菌的能力，而且經過稀釋後滅菌效果仍然不錯。
關鍵字
無資料並列摘要
Two glutaraldehydes, acid glutaraldehyde (sonacide)® and alkaline glutaraldehyde (cidex)® were evaluated for their bactericidal effect under different conditions. Two percent acid and alkaline glutaraldehyde could destroy vegetative bacteria and spores in twenty minutes. Less than 2.9 percent residual contamination rate could be achieved after immersing equipment in 0.1 percent acid glutaraldehyde or 0.5 percent alkaline glutaraldehyde for 30 minutes. Complete sterilization could be obtained by using two percent acid glutaraldehyde, while 0.5 percent residual contamination was noted after equipment had been immersed in two percent alkaline glutaraldehyde for one month. Acid glutaraldehyde could destroy bacteria completely in 30 minutes even after the solution had been standing for one month, but alkaline glutaraldehyde had an 11.4 to 26.9 percent residual rate. There were no deleterious effects on metal equipment after immersing for 14 days, but yellowish discoloration and hardening were observed on plastic and rubber equipment. It is concluded that both of these two glutaraldehydes are effective bactericides, but acid glutaraldehyde is more effective even after standing for one month or after dilution.