- 期刊
蕈樣肉芽腫－一病例報告
Mycosis Fungoides – Report of a Case
摘要
一位61歲女性在顏面、軀幹及手臂出現紫紅色斑疹及浸潤性斑塊伴痒的症狀及皮屑已有兩年。局部表在性淋巴結沒有腫大，末梢血液抹片無異型淋巴球。皮膚組織病理顯示表皮內有淋巴球親表皮現象（epidermotroism），但未形成明顯的Pautrier microabsess；表皮及真皮內有異型淋巴球浸潤。以免疫組化學染色及單株抗體反應，真皮內部份浸潤細胞對OKT4、OKT8及OKT11呈陽性反應且顯示這些浸潤細胞以helper T－細胞為主。電子顯微鏡檢查在真皮內有呈腦回狀及周邊緻密的染色質之細胞核的細胞。經臨床及病診斷為表皮Ｔ－細胞淋巴瘤中的蕈樣肉芽腫（mycosis fungoides）－斑塊期之後，病患接受UVA治療，但因身體狀況惡化而停止治療。
關鍵字
無資料並列摘要
A 61-year-old female suffered from scaly, violaceous, reddish patches and plaques on the face, trunk and upper arms for two years. Histopathology showed that atypical lymphocytes had infiltrated the epidermis and dermis. Epidermotropism was noted but Pautrier microabscesses was not identified. The electron microscopy revealed the atypical lymphocytes had convoluted contour and peripheral hyperchromatic nuclei. By immunohistochemical study, the labelling OKT4, OKT8 and OKT11 was positive for the cells, which appeared in the majority of helper T-cells, infiltrating the dermis. The diagnosis was mycosis fungoides, plaque stage. The patient received UVA therapy for 3 months but discontinued due to a worsening of her physical condition.