- 期刊
The Effects of Hyperthyroidism on MIBG Uptakes in the Human Heart-Preliminary Report
甲狀腺高能症於人類心臟之MIBG攝取的影響：初報
摘要
本研究包括12位甲狀腺高能症且合併心臟症候之病患（4位男性，8位女性，年齡分佈：20至70歲）及12位甲狀腺功能正常之對照組。每位研究對象接受劑量為每1.7平方公尺面積靜脈注射0.5毫居里之碘－131MIBG。且於注射後24及48小時接受包括全心及肺部之前胸位照影，並以下列公式評估心臟交感神經分佈之情況；H/L：（心臟每單位面積之平均計數/肺部每單位面積之平均計數）。結果顯示24及48小時之H/L於對照組比甲狀腺高能症病患為高，但無統計上之明顯差異存在。同時，對於甲狀腺高能病患比較其24小時之碘－131甲狀腺攝取值與24小時H/L之值，結果顯示並無良好相關性存在。因此我們的結論認為於甲狀腺高能患者之臨床心臟症狀表現並不完全因為交感神經分佈增加所致。
關鍵字
無資料並列摘要
Twelve cases of hyperthyroidism with cardiac manifestations (4 males, 8 females, ages: 20 to 70 years) and 12 normal controls of euthyroidism (6 males, 6 females, ages: 27 to 70 years) were included in our study. Each case accepted an I.V. injection of I-131 MIBG (I.R.E., Belgium) with 0.5mCi/1.7m2 of body surface area. The 24 and 48 hr imagings of the anterior chest, including total heart and lungs, were used to estimate cardiac sympathetic nerve innervation by the following formula: H/L = (the mean counts of pixels in the regions of interest (ROI) over the heart)/ (the mean counts of pixels in the ROI over the lungs). The results showed that the 24 and 48 hr H/L values in euthyroidism were a little higher than those in hyperthyroidism , but the differences were not significant by a Wilcoxon rank sum test. The correlation between H/L and 24 hr I-131 thyroid uptake in patients with hyperthyroidism were also evaluated and the results showed no significant correlation between the H/L and uptake. In conclusion, we consider that the clinical manifestations concerning the heart in hyperthyroidism may not totally depend on the effects of increased cardiac sympathetic nerve innervation.