應用Mebendazole治療臺南市國民小學罹患蟯蟲症學童之結果的評估

臺南市六所國民小學中，計2,471名學童感染蟯蟲。包括博愛、永華、附小、寶仁、和新南五所國民小學罹患蟯蟲症的學童為治療組，並給予單一劑量的100mg mebendazole治療，而石門國小則給予安慰劑，當為對照組。治療後三個星期，檢查陽性學童陰轉率，治療後二個月，全面檢查六所國氏小學學童蟯蟲感染率。檢查方法，為連續兩天玻璃膠紙肛圍攛拭法。陽性降低率，乃用於評估治療成效，其依據治療前和治療後學童的感染率來計算。結果顯示，由高而低依次為寶仁（62.1%）、附小（47.8%）、永華（41.8%）、博愛（37.1%）、新南（3.3%），而對照組的石門國小陽性降低率為3.9%。又觀察由學校各年級或班級所獲得數據，亦顯示治療成效的不穩定性。因此僅由單一劑量的藥物治療及個人衛生教育宣導，並不足以有效降低蟯蟲症的流行。乃因蟯蟲生活週期較短，意圖切斷傳佈途徑很困難，而且涉及本病流行的因素很很複雜。整體而言，給於藥物治療二個月後，雖然由新南國小的陽性低率顯示，對降低蟯蟲感染幾乎沒有幫助，但其他四所國民小學，卻得到有價值的性降低率。唯持續以三個月為壹期的治療過程，是否可抑制蟯蟲症的流行，仍須進一步研究評估。

關鍵字

無資料

並列摘要

There were 2,471school children suffering from enterobiasis in six primary schools of Taiwan city. The infected children in five primary schools, Po-Ai, Yung-Hua, Fu-Hsiao, Pao-Jeng and Hsin-Nan, were treated with one single dosage of 100 mg mebendazole. In Shih-Men primary school, the sixth, the students were given placebos as a control group. Negative conversion rates of infected children were examined after three weeks of chemotherapy and school children in the six primary schools were surveyed for enterobiasis two months after chemotherapy to obtain infection rates. The method of examination was two consecutive-day adhesive cellophane perianal swabs. With the purpose of evaluating the efficiency of treatment, positive reduction rates were used and calculated according to the ifection rates of school children gained before and after chemotherapy. Those rates in Pao-Jeng, Fu-Hsiao, Yung-Hua, Po-Ai and Hsin-Nan were 62.1%, 47.8%, 41.8%, 37.1% and 3.3%, respectively, and in Shih-Men 3.9%. Judging the data obtained from each grade or each class of schools showed that the efficacy of chemotherapy in reducing the rate of infection was variable. Hence, one single dose of mebendazole and education on personal hygiene were not sufficient to reduce the prevalence of enterobiasis in primary schools. This was because the cycle of E. vermicularis was relatively short, cutting out the routes of transmission was very difficult, and the factors involved were very complex. Overall, though the positive reduction rate presented in Hsin-Nan primary school showed nearly no success in reducing the infection, the other four schools showed valuable rates. Whether continue a treatment, of about three-months in duration, can inhibit the prevalence of enterobiasis among children in primary schools or not will need further study.

並列關鍵字

pinworm infection ； enterobiasis among children ； mebendazole treatment

國際替代計量

應用Mebendazole治療臺南市國民小學罹患蟯蟲症學童之結果的評估

全文下載

主題瀏覽