- 期刊
Effect of Coffee on Solid-phase Gastric Emptying in Patients with Non-ulcer Dyspepsia
咖啡對非潰瘍性消化不良病人固態胃排空影響之研究
摘要
咖啡近年來亡庈國人常用飲料之一，然而其對胃排空之影響卻少有前人研究過。本研究的目地是探討咖啡對非潰瘍性消化不良病人固態食物胃排空之影響。二十一位非潰性消化不良病人，胃鏡檢查正常或僅有表淺性胃炎，病人卻有脹氣、飽脹感等胃蠕動異常症狀。病人共接受兩次核醫閃爍造影術。第一次用同位素固態食物加上葡萄糖水當做對照組，第二次則再加上咖啡當做實驗組，將兩次檢查結果做一比較。研究結果二十一位病人中有一位喝咖啡後胃排空時間縮短，六位延長，其餘十四位不變。兩次檢查結果的差異在統計上沒有意義。根據文獻，咖啡俱有許多特性，如促進胃素分泌、微酸性、熱量、滲透壓、以及一些養分物質皆有抑制胃排空的效果，但檢查結果胃排空時間並未延長。我們根據這樣的結果推論，咖啡中可能含有娛種促進胃蠕動的物質，但因咖啡所造成的腸胃反射將它抑制了，互相抵銷的結果使咖啡對胃排空的淨影響成為沒有差異。
關鍵字
無資料並列摘要
The purpose of this study was to evaluate the effect of coffee on solid phase gastric emptying in patients with non-ulcer dyspepsia (NUD). Twenty-one NUD patients with an endoscopic negative finding or superficial gastritis were included in this study. Radionuclide labeled solid meals were used to assess the gastric emptying times (GET) of the stomach. A control meal was composed of radionuclide solid meal and 500ml 5% of glucose water. The study meal laws made from addition of 4g of instant coffee into the control meal. Of the 21 total cases, 1 demonstrated prolonged GET, 6 had shortened GET, and the other 14 showed no significant difference in GET. There were no statistically significant difference (p＞0.05) between the control and the study meal after coffee intake. Our data suggests that there may be come ingredient in coffee that promotes gastric motility, but this effect is counteracted by intestinal feedback, and the net effect is not significant.