- 期刊
The Physiologic and Pathologic Roles of Tamm-Horsfall Glycoprotein in Urinary System
Tamm-Horsfall醣蛋白在泌尿系統的生理及病理上所扮演的角色
摘要
Tamm-Horsfall醣蛋白（Tamm-Horsfall glycoprotein, THG）是一種僅由腎臟Henle蹢係的上行肥厚肢以及遠端蟠曲細尿管前節的上皮細胞所產生的特異醣蛋白。此蛋白為構成尿中透明圓柱的主要成分。在生理範圍之內會因電解質濃度的增加以及pH值的變化，使得本蛋白聚合而形成膠質狀，而影響腎細尿管對於水的通透性。由於對正常淋巴球有雙面效果而具強力的免疫調節機能。因對細胞激素有黏著作用，使得腎臟成為細胞激素代謝的主要器官。又因此醣蛋白具有聚合的特性，在許多的細小管間質疾病上會使本蛋白持續囤積於腎間質組織內，而引起間質性腎炎等的病理變化。在泌尿道感染，逆流性腎病變，以及慢性活動性肝炎時會誘發抗體產生而引起腎小管間質腎炎。測定尿液中的THG或血清抗體的存在將有助於腎尿管疾病的診斷。
關鍵字
無資料並列摘要
Tamm-Horsfall glycoprotein (THG), a unique renal glycoprotein, is synthesized exclusively by the epithelial cells of the thick ascending loop of Henle and early segment of distal convoluted tubules. The protein is the primary constituent of urinary hyaline cast. The aggregation and gel formation of THG in response to increasing concentrations of electrolytes and low pH within physiologic ranges may affect the permeability of water in this segment. The dual effect of THG on mononuclear cells renders the mononuclear cells renders the monlecule to become a potent immunomodulator. The cytokine-binding activity of THG lets the kidney an important tissue for cytokine catabolism. The aggregation characteristics of THG also plays a role in pathologic states and leads to the persistence of interstitial deposits in several tubuloniterstitial diseases. The induction of immune responses to this protein, including urinary tract infection, reflux nephropathy chronic active hepatic damage, elicties immune complex tubulointerstitial nephritis. It is expected that the detection of THG or its antibodies may aid in the diagnosis of renal tubular disorders.