- 期刊
The Relationship of Alveolar Permeability and Pulmonary Inflammation in Patients with Systemic Lupus Erythematosus
全身紅斑性狼瘡病患之肺部發炎與肺泡通透性的關係
摘要
本研究利用Tc-99m DTPA之放射性霧氣入來評估34位全斑性狼癐（SLE）病患的肺泡上皮通透性（AP），並以動態肺部照影所畫出的活性一時間曲線（time-activity curve）求得斜率（slope）來表示AP損傷的程度。我們將這些病人各依下列標準分成兩小組：(A)依臨床症狀分成穩定期及活動期；(B)依胸部X光照影分為有或無異常。另外，我們還以Ga 攝取指數（GUI）來評估SLE病人肺部發炎的嚴重度。研究結果顯示(1)不論是根據臨床症狀或胸部X光所分成的兩小組之間，AP損傷的程度皆沒有明顯的差異，(2)AP損傷程度與肺部發炎程度之間並沒有很好的關聯性。我們得到以下的結論，(1)SLE病人AP損傷的機轉或許和造成臨床症狀或胸部X光變化的機轉有所不同；(2)SLE病人AP損傷的程度與其肺部發炎的嚴重度沒有顯著關聯。
關鍵字
無資料並列摘要
The alveolar epithelium permeability (AP) in 34 patients with systemic lupus erythematosus (SLE) was measured by Tc-99m DTPA radioaerosol inhalation lung scintigraphy. The degree of AP damage in SLE was represented as the slope of the time-activity cure from the dynamic lung imagings. The patients were divided into two subgroups according to the following two criteria. [A] clinical feature: they were separated as stable or flare stage; and [B] chest X-ray findings: they were separated as positive or negative results. Meanwhile, the quantitative Callium-67 (Ga) lung scan was performed as Ga uptake index (GUI) to evaluate the severity of inflammation in the lungs in SLE. The results show that [1] there were no significant statistical differences in the degree of AP damage between the two subgroups according to clinical features or chest X-ray findings, and [2] no good correlation between the degree of AP damage and inflammation of the lungs was found. In conclusion, the change of AP in SLE may be a mechanism not related to the presentation of clinical features or chest X-ray findings, and the degree of AP damage in SLE is not related to the severity of pulmonary inflammation.