- 期刊
Changes of Circulating Leptin Levels During Normal Menstrual Cycle: Relationship to Estradiol and Progesterone
正常月經週期肥胖激素之變化：與雌激素及黃體素之關係
摘要
最近的研究顯示卵巢激素對肥胖激素的分泌有調節作用。為了探討雌二醇激素及黃體素在正常月經週期中 • 與肥胖激素之相關關係。本研究之對象為 23 位健康且有正常體重及月經之婦女。於卵泡期第 3 、 7 、 10 天及排卵前、黃體中期、黃體後期，共抽血六次做肥胖激素、雌二醇激素、黃體素、黃體化激素及卵泡刺激素之測定分析。研究結果顯示，健康婦女之肥胖激素在整個正常月經週期中，無論是卯泡期第 7 天、卵泡期第 10 天、排卵前期或黃體中期、黃體後期，其血中濃度與卵泡期第 3 天相較，並無有意義之變化。且卵泡期第 3 天及 7 天之肥胖激素與雌二醇激素問，並無有意義之相關關係，而卵泡期第 10 天與排卵前期之肥胖激素與雌二醇激素間，亦無有意義之相關關係。另一方面，黃體中期與黃體後期之肥胖激素與雌二醇激素、肥胖激素與黃體素之問，統計上亦無有意義之相關。此研究結果顯示正常月經週期婦女之肥胖激素，在整個正常月經週期問，並無有意義之變化，換言之，生理濃度之雌二醇激素及黃體素，並無影響肥胖激素之分泌作用。
關鍵字
無資料並列摘要
A possible role of ovarian steroids on the modulation of leptin production has recently been suggested. To investigate the relationship between leptin and ovarian steroids during the normal menstrual cycle, twenty-three healthy, normal-weight women were enrolled in the study. Blood was collected into chilled EDTA tubes on cycle days (D) 3, 7, 10, preovulatory (D13-15), midluteal (D 21-23) and late luteal (D 25-27) phases. Plasma leptin, estradiol (E2), progesterone (P), luteinizing hormone (LII) and follicle-stimulating hormone (FSH) were measured by RIA. Leptin levels showed no significant changes throughout the follicular (D7 and D10), preovulatory (8.6 ± 0.5 ng/mL), midluteal (8.9 ± 0.6 nglmL) and late luteal (7.7 ± 0.4 ng/mL) phases, as compared with those of D3 (7.4 ± 0.5 ng/mL) level. There was no positive correlation between leptin and E2levels in D 3 and D 7 (r = 0.14, P＞0.05) or in D 10 and preovulatory day (r 0.25, P＞0.05). Also, no positive correlation between leptin and E2 (r = 0.12, P＞0.05) or leptin and P (r = 0.17, P＞0.05) levels were observed in the mid- and late luteal phases. These data clearly indicate that physiological alterations of circulating E2 and P concentrations have no significant influence on the leptin changes during normal menstrual cycle.