- 期刊
Citalopram-Induced Serotonin Syndrome: A Case Report
Citalopram引起之血清素症候群－病例報告
摘要
血清素症候群是一種由於使用單一種血清素抑制劑，或合併使用其他藥物所造成血清素接受器過度刺激的副作用。我們發現一位三十二歲接受抗憂鬱藥物治療的男性，由於服用加倍劑量的citalopram之後；突然出現情緒不安、冒冷汗、自覺發熱感、肢體顫抖及失眠的症狀。經門診治療停用citalopram一週之後，上述臨床症症狀逐漸緩解。這是一則少見的合併藥物治療中，citalopram導致的血清素症候群案例。縱使臨床上，發生血清素症候群的機率不高，但隨著憂鬱症被人重視且抗憂鬱藥物的使用日漸頻繁。臨床醫師應該對血清素症候群有進一步的認識與瞭解。
並列摘要
Serotonin syndrome is a disorder resulting from excess stimulation of serotonin and is associated with drug interaction, single-drug therapy, and overdose. We report a case involving a 32-year-old man who developed sudden agitation, diaphoresis, subjective fever, tremor, and insomnia. These symptoms were related to doubling the dose of citalopram in combination antidepressant therapy. Discontinuation of the agent resulted in early notable clinical resolution after 1 week. This is a rare report of serotonin syndrome induced by citalopram polytherapy. Although serotonin syndrome is rare, clinicians need to recognize it early.