- 期刊
Angiotensinogen and Angiotensin Ⅱ Type 1 Receptor Gene Polymorphisms and Changes in Repolarization Parameters in Elderly Chinese: A 4-Year Follow-Up Study
在老年華人身上血管緊縮素原[-6G>A]，血管緊縮素Ⅱ第一型受器[1166A>C]基因多形性和再極化參數的變化－4年的追蹤研究
摘要
Ventricular repolarization abnormality plays a crucial role in cardiac arrhythmia. Polymorphisms in renin-angiotensin system genes are associated with occurrence of ventricular arrhythmia. We previously demonstrated that subjects carrying the angiotensin converting enzyme (ACE) D-allele but not the angiotensinogen (AGT) M235T polymorphism had a higher magnitude of QT dispersion (QTd) prolongation. The aim of this study was to test whether the AGT [-6G＞A] and angiotensin Ⅱ type 1 receptor (AT1R) [1166A＞C] polymorphisms influence repolarization parameters, including QTd and the peak and end of the T wave interval (Tpe). Of 1,500 people screened, 106 normotensive, non-diabetic participants aged≥60 were recruited. ECGs were recorded at baseline and in the second and fourth years. QTd and Tpe were manually calculated. Gene polymorphisms were analyzed by polymerase chain reaction. Mean age was 72.7±4.1 years (range, 62-81 years). QTd and Tpe were significantly prolonged in the second and fourth years (all p＜0.001). Neither gene polymorphism was associated with the magnitudes of QTd and Tpe prolongations. This longitudinal study shows that the ATIR [1166A＞C] and AGT [-6G＞A] polymorphisms do not influence repolarization parameters in this Chinese population in Taiwan, and so are not suitable markers to identify individuals susceptible to changes in these parameters.
並列摘要
Ventricular repolarization abnormality plays a crucial role in cardiac arrhythmia. Polymorphisms in renin-angiotensin system genes are associated with occurrence of ventricular arrhythmia. We previously demonstrated that subjects carrying the angiotensin converting enzyme (ACE) D-allele but not the angiotensinogen (AGT) M235T polymorphism had a higher magnitude of QT dispersion (QTd) prolongation. The aim of this study was to test whether the AGT [-6G＞A] and angiotensin Ⅱ type 1 receptor (AT1R) [1166A＞C] polymorphisms influence repolarization parameters, including QTd and the peak and end of the T wave interval (Tpe). Of 1,500 people screened, 106 normotensive, non-diabetic participants aged≥60 were recruited. ECGs were recorded at baseline and in the second and fourth years. QTd and Tpe were manually calculated. Gene polymorphisms were analyzed by polymerase chain reaction. Mean age was 72.7±4.1 years (range, 62-81 years). QTd and Tpe were significantly prolonged in the second and fourth years (all p＜0.001). Neither gene polymorphism was associated with the magnitudes of QTd and Tpe prolongations. This longitudinal study shows that the ATIR [1166A＞C] and AGT [-6G＞A] polymorphisms do not influence repolarization parameters in this Chinese population in Taiwan, and so are not suitable markers to identify individuals susceptible to changes in these parameters.