- 期刊
含鹽蘇打漱口水對緩解癌症病人口腔黏膜炎之成效
Effecting of Gargling With Salt-Soda Mouthwash in Relieving Oral Mucositis in Cancer Patients
摘要
本研究旨在探討1%含鹽蘇打漱口水，對緩解癌症病人口腔黏膜炎發生率、嚴重程度、口腔疼痛及生活品質的影響。採類實驗研究設計，研究對象為某醫學中心入院接受化療≥兩天、年齡≥18歲、無口腔黏膜炎、未使用其他漱口水者、化療前已完成牙科會診，會正確使用軟毛牙刷刷牙，並完成洗牙或補牙者；最後選取對照組33人，實驗組35人，實驗組介入1%含鹽蘇打漱口水，對照組則常規使用nystatin漱口水。研究工具係以WHO口腔黏膜評估表、Wong-Baker臉譜疼痛評估表及EORTC QLQ-C30生活品質問卷，於化療前、後第1天至第21天為止，每日評估口腔黏膜評估表及口腔疼痛評估表，共計22次；化療前及化療後每7天評估整體健康及生活品質，共計4次。結果發現（一）兩組口腔黏膜炎發生率、開始、癒合及口腔黏膜炎持續時間，皆無統計上顯著性差異；（二）口腔黏膜炎嚴重程度及口腔疼痛部份，雖然兩組無統計上顯著差異，但對照組口腔黏膜炎嚴重程度比實驗組嚴重，而實驗組口腔疼痛平均分數卻比對照組高；（三）比較兩組在化療前、後整體健康及生活品質，無統計上顯著差異。研究結論為化療病人使用1%含鹽蘇打漱口水與nystatin漱口水，對口腔黏膜炎的預防效果相仿，且口腔黏膜炎嚴重程度比使用nystatin漱口水低，惟未達顯著意義，但因其味道較緩和，故可做為癌症病人化療時漱口的另一種選擇。
並列摘要
This study aims to explore the effect of 1% salt-soda mouthwash on alleviating the incidence, severity, oral pain and quality of life of cancer patients with oral mucositis. The method was to adopt a quasi-experimental research design. The subjects of the study were those who were admitted to a medical center and received chemotherapy for ≥ 2 days, were aged ≥ 18 years, had no oral mucositis, did not use other mouthwashes, had completed dental consultation before chemotherapy, and could use soft bristles correctly, those who brushed their teeth with a toothbrush and completed tooth cleaning or filling; finally, 33 people were selected from the control group and 35 people from the experimental group. The control group used nystatin mouthwash regularly, while the experimental group used 1% salt-soda mouthwash. The research tools are WHO Mucositis Grade, Wong-Baker Faces Pain Rating Scale and EORTC QLQ-C30 quality of life questionnaire. The oral mucosal assessment form and oral pain assessment form are evaluated daily from the 1st to the 21st day before and after chemotherapy, a total of 22 times; overall health and quality of life were assessed before chemotherapy and every seven days after chemotherapy, a total of 4 times. Result: (1) There was no statistically significant difference in the incidence, onset, healing and duration of oral mucositis between the two groups; (2) There was no statistically significant difference in the severity of oral mucositis and oral pain between the two groups, but the severity of oral mucositis in the control group is higher than that in the experimental group, while the oral pain in the experimental group is more obvious than that in the control group; (3) Comparing the overall health and quality of life between the two groups before and after chemotherapy, there is no statistical difference between the two groups, but the quality of life of the experimental group was better than that of the control group. Concluded：The 1% salt-soda mouthwash in chemotherapy patients has a similar preventive effect on oral mucositis as nystatin mouthwash. The study results show that the severity of oral mucositis is lower than that using nystatin mouthwash, but it does not reach significance, and because its taste is mild, it can be used as another choice for cancer patients to rinse their mouth during chemotherapy.