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Contribution of Regional Circulations to the Pulmonary Edema and Hemorrhage Induced by Epinephrine

腎上腺素引發肺水腫及出血中局部循環之參與程度

Abstracts


在麻醉及切除迷走神經後之大白鼠,利用靜脈注射大劑量的腎上腺素以引發肺水腫及出血。注射腎上腺素100及200微克/公斤後之肺指數(肺重/體重×100)分別為1.46±0.20及1.78±0.24。除去雙腿及尾部之循環後,肺水腫及出血之程度稍微減輕,肺指數分別為1.24±0.18(腎上腺素100微克/公斤)及1.54±0.19(200微克/公斤)。結紮腹部主動脈及腔靜脈後,由於腎上腺素引起的肺病變明顯減輕,其肺指數分別為0.62±0.10(腎上腺素100微克/公斤)及0.71±0.09(200微克/公斤),僅略高於正常之肺指數0.54±0.06。分析局部循環參與此肺病變之百分比,結果顯示:對於注射腎上腺素100及200微克/公斤引起肺水腫及出血中,橫膈以上的循環僅分別參與8.7%及13.7%,而雙腿合尾部循環分別供給23.9%及21.0%之病變。最主要的部位為腹腔循環,由於注射腎上腺素引起全身血管收縮,移積血量於肺部而產生肺水腫及出血,65%以上的病變乃由於腹部循環血量減少而引起。

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Parallel abstracts


Chen, H. I., S. J. Chen, L. Kuo, and S. D. Tzeng. Contribution of regional circulations to the pulmonary edema and hemorrhage induced by epinephrine. Chinese J. Physiol. 22(4): 141-148, 1978. In anesthetized and vagotomized rats, pulmonary edema and hemorrhage (PEH) was induced by a large intravenous dose of epinephrine (EP). The values of lung index (LI), which denotes the lung wt/body wt X 100, were 1.46±0.20 and 1.78±0.24 (mean±SD) respectively after an injection of EP, 100 and 200 μg/kg. Exclusion of the hindquarters circulation slightly reduced the extent of PEH, the LI being 1.24±0.18 and 1.54±0.19 for EP of 100 and 200 μg/kg. After occlusion of the abdominal aorta and vena cava, the degree of PEH was greatly reduced. The values of LI were 0.62±0.10 and 0.71±0.09, respectively following an EP injection of 100 and 200 μg/kg. These values were only slightly higher than the normal value of0.54±0.06.An analysis was made to evaluate the relative contribution of regional circulations to the PEH induced by EP. For an injection of EP 100 and 200 μg/kg, the supra-diaphragmatic circulation contributes 8.7% and 13.7% respectively, while the hindquarters circulation 23.9% and 21.0% respectively of the total pulmonary changes. The most significant portion of the circulation is the abdominal circulation which contributes 67.4% and 65.3% to the PEH induced by EP of 100 and 200 μg/kg, respectively.

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