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Contribution of Regional Circulations to the Pulmonary Edema and Hemorrhage Induced by Epinephrine





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Chen, H. I., S. J. Chen, L. Kuo, and S. D. Tzeng. Contribution of regional circulations to the pulmonary edema and hemorrhage induced by epinephrine. Chinese J. Physiol. 22(4): 141-148, 1978. In anesthetized and vagotomized rats, pulmonary edema and hemorrhage (PEH) was induced by a large intravenous dose of epinephrine (EP). The values of lung index (LI), which denotes the lung wt/body wt X 100, were 1.46±0.20 and 1.78±0.24 (mean±SD) respectively after an injection of EP, 100 and 200 μg/kg. Exclusion of the hindquarters circulation slightly reduced the extent of PEH, the LI being 1.24±0.18 and 1.54±0.19 for EP of 100 and 200 μg/kg. After occlusion of the abdominal aorta and vena cava, the degree of PEH was greatly reduced. The values of LI were 0.62±0.10 and 0.71±0.09, respectively following an EP injection of 100 and 200 μg/kg. These values were only slightly higher than the normal value of0.54±0.06.An analysis was made to evaluate the relative contribution of regional circulations to the PEH induced by EP. For an injection of EP 100 and 200 μg/kg, the supra-diaphragmatic circulation contributes 8.7% and 13.7% respectively, while the hindquarters circulation 23.9% and 21.0% respectively of the total pulmonary changes. The most significant portion of the circulation is the abdominal circulation which contributes 67.4% and 65.3% to the PEH induced by EP of 100 and 200 μg/kg, respectively.