- 期刊
Thyrotrophic-Releasing Hormone Induces Fever in Rabbits
親甲狀腺素釋放激素(TRH)引致白兔發燒
摘要
自清醒的白兎第三腦室注入微量的TRH引致肛溫急速上昇。在攝氏二及二十二度的低及中溫環境中，TRH提昇新陳代謝率及降低皮膚血流量因而引致發燒。在攝氏三十二度的高溫環境中，TRH降低皮膚血流量及呼吸道散熱因而引致發燒。腦內給予阿波嗎啡（妥巴胺接受體之興奮劑）亦引起相同的發燒反應。由本結果推論：TRH之發燒作用可能與腦中樞的妥巴胺系統有關係。
關鍵字
無資料並列摘要
The changes in metabolic, respiratory and vasomotor activities as well as body temperatures produced by an injection of thyrotrophic-releasing hormone(TRH)into the third cerebral ventricle of unanes-thetized rabbits were assessed at three different ambient temperatures(T(subscript a))of 2,22 and 32℃. At all T(subscript a) studied, intraventricular administration of TRH(5-20 μg) produced dose-dependent fever which was almost immediate in onset. Ambient temperature influenced the thermoregulatory mechanisms by which TRH fever evolved. In the cold(2℃ T(subscript a)), TRH fever was brought about by increased metabolism while in moderate environmental temperature (22℃ T(subscript a)) skin blood flow was reduced and metabolism was increased without significant changes in respiratory evaporative heat loss. In the heat(32℃ T(subscript a)), reduction in both evaporative and dry heat losses was effective in producing fever along with a small rise in heat production. The data indicate that TRH increases heat production and decreases heat loss which leads to fever in conscious rabbits.