Extra low carbon IF steels with different alloy contents were used to develop EDDQ grade cold-rolled steels with high resistance to secondary work embrittlement. Experimental results showed that decreasing slab reheating temperature (SRT) and carbon content or increasing titanium content increased r-value of the steels. Decrease of SRT and titanium content or addition of niobium was beneficial to the resistance to secondary work embrittlement. Coiling temperature revealed little effect on transition temperature, while increasing coiling temperature decreased recrystallization temperature and material strength. Increasing cold reduction increased r-value and decreased △r value, thus promoted the resistance to secondary work embrittlement. Mill tryout showed that EDDQ grade steel was obtained with proper alloying and processing design.