This paper will focus on exploring the evolution of the concepts and issues surrounding causation and counterfactual considerations, presenting a progression from philosophical inquiry to scientific methods. First, it will examine several representative concepts of causation from ancient Greek philosophy, modern philosophy, and contemporary analytic philosophy, highlighting the evolving central role of counterfactual considerations in causation and the related unresolved issues. Second, it will explain how counterfactual considerations form the basis for causation in science, and emphasize how scientific inquiries into causal inference address relevant issues from philosophical literature. Finally, it will point out some ongoing issues in causation that are still under development in both philosophy and science.