The baryon asymmetry of the Universe requires CP violation, but the Standard Model falls short by a factor of 10^(-10) or more. Starting from a clue at the B factories, we point out that the large Yukawa couplings of the sequential fourth generation t' and b' quarks can provide enhancement by a factor of over 10^13, making the 2-3-4 generation quark sector a viable source of CP violation for the baryon asymmetry of the Universe. With recent hints of a large sin 2ΦB(subscript s) in B(superscript 0 subscript s)-(average)B(superscript 0 subscript s) mixing from the Tevatron, the ultimate test would be to discover the t' and b' quarks at the Large Hadron Collider.