The Roles of Time Delay and Colored Noises on the Interspike Intervals of Calcium Spikes

Wei-Long Duan

《Chinese Journal of Physics》 預刊文章 Pp. i1-7

https://doi.org/10.6122/CJP.20140602

並列摘要

In view of the same time delay in active and passive transport processes with colored noises of intracellular Ca^(2+), the interspike intervals (ISI) of calcium spikes of the intracellular calcium oscillation (ICO) are investigated by means of a second-order algorithm for the stochastic simulation of colored noises. Because the ICO exhibits anti-synchronous oscillation, thus we respectively compute the average ISI and its standard deviation (SD) of calcium spikes in the cytosol and endoplasmic reticulum (ER) with different time delays and strengths of colored noises. The results indicate that: (i) the average ISI are equal for the cytosol and ER, and have linear growth as the time delay prolongs. (ii) The average ISI firstly increases then remains steady as the colored noises strengthen. (iii) However, both SDs vs. time delay show that coherence resonance occurs.