- 期刊
Vitamin K Nutritional Status and Undercarboxylated Osteocalcin in Postmenopausal Osteoporotic Women Treated with Bisphosphonates
用双磷酸盐治疗的绝经后骨质疏松妇女的维生素K的营养状况和未羧化的骨钙素浓度
摘要
血清未羧化的骨钙素（ucOC）是治疗初始的绝经后骨质疏松妇女的维生素K营养状况的指标。本研究的目的是揭示服用双磷酸盐的绝经后骨质疏松妇女维生素K 的营养状况和血清ucOC的浓度之间的关联。86位绝经后骨质疏松妇女开始双磷酸盐治疗（年龄范围47-90岁）。采用简单的维生素K摄入量调查问卷评估维生素K的营养状况，治疗6个月后测定血清中ucOC的浓度。根据简单的维生素K摄入量调查问卷评分将患者分为两组：低维生素K摄入组（得分 ＜ 40, n = 60）和正常维生素K摄入组（得分 ≥ 40, n = 19）。两组患者的基线参数包括年龄、身高、体重、体质指数、血清碱性磷酸酶（ALP）和尿N-末端肽交联的I型胶原蛋白（NTX），以及6个月治疗期间血清ALP和尿NTX浓度的变化之间没有显著差异。然而治疗6个月之后，低维生素K摄入组的平均血清ucOC浓度（2.79 ng/mL）显著高于正常维生素K摄入组（2.20 ng/mL）。这些结果表明，尽管78%用双磷酸盐治疗的绝经后骨质疏松妇女与正常维生素K摄入量的妇女有相似的骨转化降低，但从低维生素K摄入量和高血清ucOC浓度看出他们可能缺乏维生素K。
並列摘要
Serum undercarboxylated osteocalcin (ucOC) is an index of vitamin K nutritional status in treatment-naive postmenopausal osteoporotic women. The purpose of the present study was to reveal the association between vitamin K nutritional status and serum ucOC concentrations in postmenopausal osteoporotic women taking bisphosphonates. Eighty-six postmenopausal women with osteoporosis (age range: 47-90 years) initiated bisphosphonate treatment. Vitamin K nutritional status was evaluated using a simple vitamin K-intake questionnaire and serum ucOC concentrations were measured after 6 months of treatment. The patients were divided into two groups according to the simple vitamin K-intake questionnaire score: a low vitamin K-intake (score ＜ 40) group (n = 67) and a normal vitamin K-intake (score ≥ 40) group (n = 19). There were no significant differences between the groups in baseline parameters including age, height, body weight, body mass index, serum alkaline phosphatase (ALP), urinary cross-linked N-terminal telopeptides of type I collagen (NTX), and changes in serum ALP and urinary NTX concentrations during the 6-month treatment period. However, the mean serum ucOC concentration after 6 months of treatment was significantly higher in the low vitamin K-intake group (2.79 ng/mL) than in the normal vitamin K-intake group (2.20 ng/mL). These results suggest that 78% of postmenopausal osteoporotic women treated with bisphosphonates may have vitamin K deficiency as indicated by low vitamin K-intake and high serum ucOC concentrations, despite having a similar reduction in bone turnover to women who have normal vitamin K-intake.