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Dietary factors and risk of gout and hyperuricemia: a meta-analysis and systematic review

Ahead-of-Print version of this article:10.6133/apjcn.062018.01

Abstracts


Background and Objectives: To evaluate the associations of dietary factors and the risk of gout and hyperuricemia. Methods and Study Design: PubMed and Embase databases were searched from inception to June 2017 for eligible studies. Nineteen prospective cohort or cross-sectional studies with adequate sample sizes are included, all involving red meat, seafoods, alcohol, fructose, dairy products, soy foods, high-purine vegetables and coffee. Results: Meta-analysis revealed several dietary associations with gout risk: red meat: OR 1.29 (95% CI 1.16-1.44); seafoods: OR 1.31 (95% CI 1.01-1.68); alcohol: OR 2.58 (95% CI 1.81-3.66); fructose: OR 2.14 (95% CI 1.65- 2.78); dairy products: OR 0.56 (95% CI 0.44-0.70); soy foods: OR 0.85 (95% CI 0.76-0.96); high-purine vegetables: OR 0.86 (95% CI 0.75-0.98); coffee: OR 0.47 (95% CI 0.37-0.59).Dietary association with hyperuricemia risk (red meat: OR 1.24 (95% CI 1.04-1.48); seafoods: OR 1.47 (95% CI 1.16-1.86); alcohol: OR 2.06 (95% CI 1.60-2.67); fructose: OR 1.85 (95% CI 1.66-2.07); dairy products: OR 0.50 (95% CI 0.37-0.66); soy foods: OR 0.70 (95% CI 0.56-0.88); high-purine vegetables ingestion: OR 1.10 (95% CI 0.88-1.39), P=0.39; coffee: OR 0.76 in men (95% CI 0.55-1.06), OR 1.58 in women (95% CI 1.16-2.16). Conclusion: The risk of hyperuricemia and gout is positively correlated with the intake of red meat, seafoods, alcohol or fructose, and negatively with dairy products or soy foods. High-purine vegetables showed no association with hyperuricemia, but negative association with gout. Coffee intake is negatively associated with gout risk, whereas it may be associated with increased hyperuricemia risk in women but decreased risk in men.

Keywords

gout hyperuricemia risk nutrition dietary factors

Cited by


張雅惠、呂瑾立、徐宇慧、李岳蓁、黃乙芹、巫岑希、古鯉榕、李中一(2021)。國人飲用含糖飲料盛行率與其相關疾病之全民健保醫療費用估計台灣公共衛生雜誌40(3),319-331。https://doi.org/10.6288/TJPH.202106_40(3).110023

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