- 期刊
Benign paroxysmal positional vertigo and serum transthyretin in Chinese older adults
摘要
Background and Objectives: Poor nutritional status is associated with benign paroxysmal positional vertigo (BPPV). Transthyretin (TTR) is a more sensitive marker than is albumin for nutritional status assessment. This study was conducted to confirm an association between serum transthyretin levels and BPPV. Methods and Study Design: In total, 320 patients with BPPV and 320 age- and gender-matched controls were recruited between July 1, 2018, and July 1, 2020. All patients underwent audiovestibular tests, including the Dix-Hallpike test for the posterior semicircular canal and the supine roll test for the horizontal semicircular canal. Furthermore, serum transthyretin levels and other biochemical indicators were tested. Risk factors, including a history of heart and cerebral vascular diseases, were examined, and compared between groups. Hematolgical and biochemical tests were performed and subjected to between-group analysis. Multiple logistic regression models were employed to evaluate the TTR-BPPV. Interaction and stratified analyses were conducted. Results: Patients with BPPV had significantly lower TTR levels than controls (213±49.3 vs 284±56.4 p＜0.001). Alcohol consumption and anemia played an interactive role in the association between BPPV and low TTR levels. After adjustments for triglycerides, BMI, uric acid, HbA1C, 25-OH vitamin D_3, alcohol consumption, and anemia, the multiple logistic regression revealed that participants with low TTR levels had a significantly increased risk of BPPV (OR: 5.5; 95% CI, 2.55-11.9; p＜0.001). Conclusions: Chinese older adults with low serum transthyretin levels have an increased risk of BPPV.